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Skip to content Skip to search Skip to footer Developmental Biology Open Menu Back Close Menu Search for: Search Close Search Home AboutAbout Message from the Head Career Opportunities HistoryHistory Heads of the Department of Developmental Biology Department Newsletters Giving PeoplePeople Faculty Joint Faculty Research Track Faculty Emeritus Faculty ResearchResearch Model Systems PublicationsPublications 2022 Publications 2021 Publications 2020 Publications 2019 Publications 2018 Publications 2017 Publications 2016 Publications 2015 Publications 2014 Publications 2013 Publications 2012 Publications Image Gallery EducationEducation Postdoctoral Researchers Graduate Students Undergraduate Students ResourcesResources Department Resources Research Cores &＃038; Centers Workday NewsNews Research News Department News EventsEvents Calendar View Past Departmental Events Open Search 2016 Publications Robust Axonal Regeneration in a Mouse Vascularized Composite Allotransplant Model Undergoing Delayed Tissue Rejection. Yan Y, Wood MD, Moore AM, Snyder-Warwick AK, Hunter DA, Newton P, Poppler L, Tung TH, Johnson PJ, Mackinnon SE. Hand (N Y). 2016 Dec;11(4):456-463.Advances in myelinating glial cell development. Herbert AL, Monk KR. Curr Opin Neurobiol. 2016 Dec 5;42:53-60. doi: 10.1016/j.conb.2016.11.003.Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair. Mogha A, Harty BL, Carlin D, Joseph J, Sanchez NE, Suter U, Piao X, Cavalli V, Monk KR. J Neurosci. 2016 Dec 7;36(49):12351-12367.Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination. Sigoillot SM, Monk KR, Piao X, Selimi F, Harty BL. Handb Exp Pharmacol. 2016;234:275-298.Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors. Scholz N, Monk KR, Kittel RJ, Langenhan T. Handb Exp Pharmacol. 2016;234:221-247.Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice. Zhang H, Kamiya N, Tsuji T, Takeda H, Scott G, Rajderkar S, Ray MK, Mochida Y, Allen B, Lefebvre V, Hung IH, Ornitz DM, Kunieda T, Mishina Y. PLoS Genet. 2016 Dec 27;12(12):e1006510.Achondroplasia: Development, Pathogenesis, and Therapy. Ornitz DM, Legeai-Mallet L. Dev Dyn. 2016 Dec 17.Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Cell Metab. 2016 Dec 13;24(6):795-806.A novel mechanism of non-feminizing estrogens in neuroprotection. Engler-Chiurazzi EB, Covey DF, Simpkins JW. Exp Gerontol. 2016 Nov 3. pii: S0531-5565(16)30465-X.Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1. Sankar S, Yellajoshyula D, Zhang B, Teets B, Rockweiler N, Kroll KL. Sci Rep. 2016 Nov 24;6:37412.The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS. Cell. 2016 Nov 3;167(4):1137.Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. J Physiol. 2016 Nov 3.G Protein-Coupled Receptors in Myelinating Glia. Mogha A, D&＃8217;Rozario M, Monk KR. Trends Pharmacol Sci. 2016 Nov;37(11):977-987.NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion. Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. Elife. 2016 Oct 13;5.Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice. Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A. Brain. 2016 Oct 25.Structure-activity studies of non-steroid analogues structurally-related to neuroprotective estrogens. Qian M, Engler-Chiurazzi EB, Lewis SE, Rath NP, Simpkins JW, Covey DF. Org Biomol Chem. 2016 Oct 18;14(41):9790-9805.Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling. Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R. Elife. 2016 Oct 5;5.Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health. Zhang WB, Sinha DB, Pittman WE, Hvatum E, Stroustrup N, Pincus Z. Cell Syst. 2016 Oct 26;3(4):333-345.e4.Notch-Mediated Epigenetic Regulation of Voltage-Gated Potassium Currents. Khandekar A, Springer S, Wang W, Hicks S, Weinheimer CJ, Diaz-Trelles R, Nerbonne JM, Rentschler S. Circ Res. 2016 Oct 3.An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities. Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Suh JM, Atkins AR, Downes M, Evans RM, Tenorio CA, Bienkiewicz E, Blaber M. J Pharm Sci. 2016 Oct 20.TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model. Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y. Neuropharmacology. 2016 Dec;111:142-159.G Protein-Coupled Receptors in Myelinating Glia. Mogha A, D&＃8217;Rozario M, Monk KR.Trends Pharmacol Sci. 2016 Nov;37(11):977-987.SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation. Summers DW, Gibson DA, DiAntonio A, Milbrandt J. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6271-E6280.Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts. Huh CJ, Zhang B, Victor MB, Dahiya S, Batista LF, Horvath S, Yoo AS. Elife. 2016 Sep 20;5.Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D. Neuron. 2016 Sep 21;91(6):1292-304.NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Lin JB, Kubota S, Ban N, Yoshida M, Santeford A, Sene A, Nakamura R, Zapata N, Kubota M, Tsubota K, Yoshino J, Imai S, Apte RS. Cell Rep. 2016 Sep 27;17(1):69-85.The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Küffer A, Lakkaraju AK, Mogha A, Petersen SC, Airich K, Doucerain C, Marpakwar R, Bakirci P, Senatore A, Monnard A, Schiavi C, Nuvolone M, Grosshans B, Hornemann S, Bassilana F, Monk KR, Aguzzi A. Nature. 2016 Aug 25;536(7617):464-8.Adhesion G protein-coupled receptors in nervous system development and disease. Langenhan T, Piao X, Monk KR. Nat Rev Neurosci. 2016 Sep;17(9):550-61.Single-Cell RNA-Seq Steps Up to the Growth Plate.  Morris SA. Trends Biotechnol. 2016 Jul;34(7):525-7.Direct lineage reprogramming via pioneer factors; a detour through developmental gene regulatory networks. Morris SA. Development. 2016 Aug 1;143(15):2696-705.Axonal Growth Arrests After an Increased Accumulation of Schwann Cells Expressing Senescence Markers and Stromal Cells in Acellular Nerve Allografts. Poppler LH, Ee X, Schellhardt L, Hoben GM, Pan D, Hunter DA, Yan Y, Moore AM, Snyder-Warwick AK, Stewart SA, Mackinnon SE, Wood MD. Tissue Eng Part A. 2016 Jul;22(13-14):949-61.Structural basis of Smoothened regulation by its extracellular domains. Byrne EF, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MS, Newstead S, Rohatgi R. Nature. 2016 Jul 28;535(7613):517-22.Complexities of X chromosome inactivation status in female human induced pluripotent stem cells-a brief review and scientific update for autism research. Dandulakis MG, Meganathan K, Kroll KL, Bonni A, Constantino JN. J Neurodev Disord. 2016 Jun 9;8:22.The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS. Cell. 2016 Jun 16;165(7):1708-20.Insights into zinc and cadmium biology in the nematode Caenorhabditis elegans. Dietrich N, Tan CH, Cubillas C, Earley BJ, Kornfeld K. Arch Biochem Biophys. 2016 May 31.Single-Cell RNA-Seq Steps Up to the Growth Plate. Morris SA. Trends Biotechnol. 2016 Jul;34(7):525-7.Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai S, Seals DR. Aging Cell. 2016 Jun;15(3):522-30.Intracellular Golgi Complex organization reveals tissue specific polarity during zebrafish embryogenesis. Sepich DS, Solnica-Krezel L. Dev Dyn. 2016 Jun;245(6):678-91.Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, Marquardt T, Runz H, Giugliani R, Schaffer JE, Ory DS. Sci Transl Med. 2016 May 4;8(337):337ra63.FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth. Karuppaiah K, Yu K, Lim J, Chen J, Smith C, Long F, Ornitz DM. Development. 2016 May 15;143(10):1811-22.Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody. Yin Y, Ren X, Smith C, Guo Q, Malabunga M, Guernah I, Zhang Y, Shen J, Sun H, Chehab N, Loizos N, Ludwig DL, Ornitz DM. Dis Model Mech. 2016 May 1;9(5):563-71. Mutagenic and chemical analyses provide new insight into enzyme activation and mechanism of the type 2 iron-sulfur l-serine dehydratase from Legionella pneumophila. Xu XL, Grant GA. Arch Biochem Biophys. 2016 Apr 15;596:108-17.Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for &＃8220;Second Generation&＃8221; Therapeutic Application. Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Sutherland MA, Tenorio CA, Blaber M. J Pharm Sci. 2016 Apr;105(4):1444-53.A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition. Jiang X, Shu HJ, Krishnan K, Qian M, Taylor AA, Covey DF, Zorumski CF, Mennerick S. Neuropharmacology. 2016 Sep;108:193-206. doi: 10.1016/j.neuropharm.2016.04.031.TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A. J Neurosci. 2016 Apr 27;36(17):4681-9.Mandible Fracture Complications and Infection: The Influence of Demographics and Modifiable Factors. Odom EB, Snyder-Warwick AK. Plast Reconstr Surg. 2016 Apr 6.Transcaruncular Approach for Treatment of Medial Wall and Large Orbital Blowout Fractures. Nguyen DC, Shahzad F, Snyder-Warwick A, Patel KB, Woo AS.Craniomaxillofac Trauma Reconstr. 2016 Mar;9(1):46-54.Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW. Sci Rep. 2016 Mar 18;6:23326.Models of axon regeneration in Drosophila. Brace EJ, DiAntonio A. Exp Neurol. 2016 Mar 17.Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction. Bae H, Chen S, Roche JP, Ai M, Wu C, Diantonio A, Graf ER. eNeuro. 2016 Mar 12;3(2). pii: ENEURO.0031-16.2016. doi: 10.1523/ENEURO.0031-16.2016.ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation. Nishioka T, Arima N, Kano K, Hama K, Itai E, Yukiura H, Kise R, Inoue A, Kim SH, Solnica-Krezel L, Moolenaar WH, Chun J, Aoki J. Sci Rep. 2016 Mar 23;6:23433.Proteomic analysis of native cerebellar iFGF14 complexes. Bosch MK, Nerbonne JM, Townsend RR, Miyazaki H, Nukina N, Ornitz DM, Marionneau C.Channels (Austin). 2016 Feb 18:1-16.Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span. Kumar S, Dietrich N, Kornfeld K. PLoS Genet. 2016 Feb 26;12(2):e1005866.Predicting all-cause mortality from basic physiology in the Framingham Heart Study. Zhang WB, Pincus Z. Aging Cell. 2016 Feb;15(1):39-48.Ageing: A stretch in time. Pincus Z. Nature. 2016 Feb 4;530(7588):37-8.Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development. Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA. Cell Rep. 2016 Jan 5;14(1):82-92.Distinct Firing Properties of Vasoactive Intestinal Peptide-Expressing Neurons in the Suprachiasmatic Nucleus. Hermanstyne TO, Simms CL, Carrasquillo Y, Herzog ED, Nerbonne JM. J Biol Rhythms. 2016 Feb;31(1):57-67.Notch Activation Associates with Poor Outcomes in Heart Failure: is It Harmful, or Not Enough of a Good Thing? Chiplunkar A, Rentschler S. J Card Fail. 2016 Jan 14. pii: S1071-9164(16)00005-1.Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors. Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G. Mol Pharmacol. 2016 Jan 14.A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development. Hung IH, Schoenwolf GC, Lewandoski M, Ornitz DM. Dev Biol. 2016 Jan 16.Endothelial Fibroblast Growth Factor Receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury. House SL, Castro AM, Lupu TS, Weinheimer C, Smith C, Kovacs A, Ornitz DM. Am J Physiol Heart Circ Physiol. 2016 Jan 8:ajpheart.00758.2015.Cardiac Mechano-Gated Ion Channels and Arrhythmias. Peyronnet R, Nerbonne JM, Kohl P. Circ Res. 2016 Jan 22;118(2):311-29. 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