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Prospective Students Current Students Faculty & Staff Alumni Industry Start your application today Undergraduate Admissions Graduate Admissions Dual Degree Program Graduate applicants: Attend an info session and skip the application fee Search Trending Searches graduate admissions academic programs financial aid academic calendar maps & directions summer school Home News & Events A new way to deliver vaccines to the elderly without inflammation A new way to deliver vaccines to the elderly without inflammation Jai Rudra, Meredith Jackrel to use nanofibers to develop new vaccines 07.26.2021 Jai Rudra and Meredith Jackrel will test amyloid-like peptide nanofibers as materials to develop new vaccines that do not require adjuvants. (Photo credit: iStock photo) Share Share on Facebook Share on Twitter Share on Linkedin Email The SARS-CoV2 pandemic has emphasized the importance for vaccines, particularly for the elderly, who have been disproportionally impacted by the virus. However, a decline in immune response as well as inflammation accompany aging and requires an immune booster to improve the immune response.&＃160; Jai Rudra, assistant professor of biomedical engineering in the McKelvey School of Engineering, will collaborate with Meredith Jackrel, assistant professor of chemistry in&＃160; Arts & Sciences, both at Washington University in St. Louis, in a plan to develop and test a novel nanofiber material to eliminate the use of adjuvants with a two-year, $433,125 grant from the National Institutes of Health. The award funds high-risk, exploratory research for the early and conceptual stages of developing a project. Rudra proposes to test amyloid-like peptide nanofibers as materials to develop novel vaccines that do not require adjuvants. These peptide nanofibers do not require added adjuvants and are expected to trigger the autophagy pathway, a kind of cellular recycling that can also promote good immunological functions, which has emerged as a potential vaccine target. Using these peptide nanofibers leads to strong antibody responses without local reactions, making them attractive to deliver vaccines to the elderly. However, because of their similarity to amyloids that accumulate in patients with neurodegenerative diseases, such as Alzheimer&＃8217;s, Huntington&＃8217;s and Parkinson&＃8217;s, it is essential that the researchers thoroughly test the safety and clearance mechanism of the peptide nanofiber vaccines. Jackrel&＃8217;s lab focuses on developing model systems to study the toxicity and mechanism of disease-associated amyloid proteins. The two labs have already worked together to confirm that these peptide nanofibers are not toxic and have made some new insights into their mechanism of clearance. With early work near completion, Rudra&＃8217;s lab has begun work in animal systems. Once toxicity testing is completed, work will begin on testing conjugates to various vaccine targets, notably those that underpin SARS CoV-2. The McKelvey School of Engineering at Washington University in St. Louis promotes independent inquiry and education with an emphasis on scientific excellence, innovation and collaboration without boundaries. McKelvey Engineering has top-ranked research and graduate programs across departments, particularly in biomedical engineering, environmental engineering and computing, and has one of the most selective undergraduate programs in the country. 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Click on the topics below for more stories in those areas Research Biomedical Engineering Back to News Faculty in this story View Profile Jai Rudra Associate Professor Meredith Jackrel Assistant Professor of Chemistry, Arts & Sciences You may also be interested in: Novel material supercharges innovation in electrostatic energy storage Sang-Hoon Bae developed heterostructures with material properties optimal for high-density energy storage, durable ultrafast charging. 04.18.2024 Role of indoor dust on indoor environmental air quality gets closer look Jenna Ditto to study dust chemistry transformations, impact of exposure to humans. 04.18.2024 DeFake tool protects voice recordings from cybercriminals Ning Zhang is one of three winners of the Federal Trade Commission’s Voice Cloning Challenge to prevent, monitor and evaluate malicious voice cloning. 04.18.2024 Facebook Twitter LinkedIn Instagram YouTube Engineering Departments Biomedical Engineering Computer Science & Engineering Division of Engineering Education Electrical & Systems Engineering Energy, Environmental & Chemical Engineering Mechanical Engineering & Materials Science Sever Institute - professional degrees Technology & Leadership Center - training for industry Contact Us Washington University in St. Louis McKelvey School of Engineering MSC: 1100-122-303 1 Brookings Drive St. Louis, MO 63130-4899 Contact Us Resources COVID-19 Resources Canvas Directory Equity, Diversity & Inclusion Emergency Management Engineering IT Maps & Directions Make a Gift WebFAC / WebSTAC ©2024 Washington University in St. Louis. 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