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--> Search for: Home Faculty Members Departmental Information Directories Giving Webmail Home Faculty Members Departmental Information Directories Giving Webmail Search for: EFR3A-PI4KA signaling axis promotes KRAS nanoclustering and oncogenesis Cell Image Cell Image Bimodal control of DNA replication by Mec1ATR kinase Cell Image Welcome to the Department of Biochemistry and Molecular Biophysics. Precise understanding of the molecular interactions that underlie both normal physiology and disease states is the foundation for rational approaches to genetic therapies, drug design and personalized medicine. Our goal in this endeavor is to obtain a molecular understanding of mechanism (i.e., how biological molecules carry out their functions). We seek to advance our understanding of biology using the disciplines of chemistry, physics and mathematics. Our department provides a rich environment for both faculty and student growth, and we welcome inquiries. Recent News Congratulations to Jasmine Cubuk and Keri-Lyn Kozul for receiving the 2024 W.M. Keck Postdoctoral Fellowship award! This fellowship provides one year of funding to postdoctoral appointees in the early phase of their postdoctoral training who demonstrate exceptional potential for becoming leading experts in biomedical research. Dr. Jasmine Cubuk is doing her postdoctoral work in the laboratory of Dr. Andrea Soranno. Dr. Keri-Lyn Kozul is doing her postdoctoral work in the laboratory of Dr. Natalie Niemi. Congratulations to Jinping Yang for receiving the 2023 Ceil M. DeGutis Prize Fellows Award Jinping Yang is a 5th year PhD student from the Department of Chemistry. She grew up in a small town in China, where she discovered her passion for chemistry during high school. Intrigued by the profound interconnection between chemistry and the fundamental aspects of life, Jinping decided to pursue her undergraduate degree in chemistry and was supported by the Top-Notch Student Cultivation in Math and Sciences Scholarship at Xiamen University. (more…) Congratulations to Jasmine Cubuk for receiving the 2023 Ceil M. DeGutis Prize Fellows Award Jasmine Cubuk is a recent graduate in the Biochemistry, Biophysics, and Structural Biology (BBSB) program. She defended on April 21st, 2023. She did her PhD thesis work in the lab of Dr. Andrea Soranno, where she studied how sequence composition of intrinsically disordered regions within a protein can affect interactions with both proteins and nucleic acids using single-molecule fluorescence spectroscopy. (more…) Congratulations to Jenna Lin for receiving the 2024 John E. Majors Award Jenna Lin received her B.S. in Bioengineering and a minor in Biology from University of Missouri-Columbia. During her undergraduate research, Jenna developed a great interest in ion channels and electrophysiology. She began her Ph.D. studies in the Biophysics program at the University of Wisconsin-Madison in 2018 and joined the Biochemistry, Biophysics, and Structural Biology program in the Division of Biology and Biomedical Sciences at Washington University in St. Louis in 2020 when the lab relocated. (more…) More in the News Archive&＃8230; Upcoming Events [iCal show_views=0 pagination=0 listtype=50 agenda=53 https://outlook.office365.com/owa/calendar/[email protected]/0f2385abf4a444659f2e48d698be926d5474832574802115525/S-1-8-1698799985-1791686349-473769804-1513876890/reachcalendar.ics]   (Full Calendar View) --> Select Publications Venecia Valdez, Meisheng Ma, Bernardo Gouveia, Rui Zhang &＃038; Sabine Petry (2024). &＃8220;HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2&＃8221; bioRxiv. [Preprint]. 2023 Dec 18:2023.12.18.571906. doi: 10.1101/2023.12.18.571906. (Abstract) Kiarash Jamali, Lukas Käll, Rui Zhang, Alan Brown, Dari Kimanius &＃038; Sjors H W Scheres (2024). &＃8220;Automated model building and protein identification in cryo-EM maps&＃8221; Nature. 2024 Apr;628(8007):450-457. doi: 10.1038/s41586-024-07215-4. Epub 2024 Feb 26. (Abstract) Ankit Garg, Silvia Jansen, Rui Zhang, Kory J Lavine &＃038; Michael J Greenberg (2024). &＃8220;Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility&＃8221; bioRxiv. [Preprint]. 2024 Mar 12:2024.03.10.583979. doi: 10.1101/2024.03.10.583979. (Abstract) Steven L Brody, Jiehong Pan, Tao Huang, Jian Xu, Huihui Xu, Jeffrey Koenitizer, Steven K Brennan, Rashmi Nanjundappa, Thomas G Saba, Andrew Berical, Finn J Hawkins, Xiangli Wang, Rui Zhang, Moe R Mahjoub, Amjad Horani &＃038; Susan K Dutcher (2024). &＃8220;Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy&＃8221; bioRxiv. [Preprint]. 2024 Mar 21:2024.03.20.585965. doi: 10.1101/2024.03.20.585965. (Abstract) Jin Dai, Meisheng Ma, Qingwei Niu, Robyn J Eisert, Xiangli Wang, Poulomi Das, Karl F Lechtreck, Susan K Dutcher, Rui Zhang &＃038; Alan Brown (2024). &＃8220;Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices&＃8221; Cell. 2024 Apr 11;187(8):1907-1921.e16. doi: 10.1016/j.cell.2024.03.005. Epub 2024 Mar 28. (Abstract) Gabor Egervari, Desi C. Alexander, Greg Donahue, Hua Huang, Connor Hogan, Mariel Mendoza, Benjamin A. Garcia, Nancy M. Bonini, Shelley L. Berger (2024). &＃8220;ACSS2 contributes to transcriptional regulation in Cajal-Retzius cells in a mouse model of Alzheimer’s disease&＃8221; bioRxiv. [Preprint] (Abstract) Jasmine Cubuk, Lina Greenberg, Akiva E Greenberg, Ryan J Emenecker, Melissa D Stuchell-Brereton, Alex S Holehouse, Andrea Soranno &＃038; Michael J Greenberg (2024). &＃8220;Structural dynamics of the intrinsically disordered linker region of cardiac troponin T&＃8221; bioRxiv. [Preprint]. 2024 May 31:2024.05.30.596451. doi: 10.1101/2024.05.30.596451. (Abstract) Eva Fortea, Sangyun Lee, Rahul Chadda, Yiorgos Argyros, Priyanka Sandal, Robyn Mahoney-Kruszka, Hatice Didar Ciftci, Maria E Falzone, Gerard Huysmans, Janice L Robertson, Olga Boudker &＃038; Alessio Accardi (2024). &＃8220;Structural basis of pH-dependent activation in a CLC transporter&＃8221; Nat Struct Mol Biol. 2024 Apr;31(4):644-656. doi: 10.1038/s41594-023-01210-5. Epub 2024 Jan 26. (Abstract) Past Events 2024 BMB Department RetreatOn May 20th, 2024, the BMB Department held its retreat at the Donald Danforth Plant Science Center. Several members of the department gave presentations on what they are working on in their lab. You can click here to view photos from the event. 2022 BMB and CB&＃038;P Softball Game August 31st, 2022 &＃8211; The departments of Biochemistry and Molecular Biophysics and Cell Biology &＃038; Physiology had lunch and played a softball game together. The final score was BMB 17, CB&＃038;P 14! You can click here to view photos from the event. Wellness Session &＃8211; Krista JarvisOn April 28th, 2021, the Department hosted a special session entitled “Evidence-based Practices that Support Mental and Emotional Well-being”. Mrs. Krista Jarvis, Clinical Case Manager and Program Manager in the Department of Psychiatry at Washington University, walks the group through five different evidence-based practices for our mental and emotional well-being. These practices are designed to help each individual feel empowered to utilize a variety of simple techniques for stress-reduction in these challenging times. If you would like to view this, just click here. Working Smarter &＃8211; Strategic Planning &＃038; Time Management BasicsOn March 5th, 2021, Dr. Thi Nguyen presented on &＃8220;Working Smarter &＃8211; Strategic Planning &＃038; Time Management Basics&＃8221;. To watch this presentation, please click here. More in the Events Archive&＃8230; Research Awards September 11th, 2023 – James Janetka, PhD, Professor in the Department of Biochemistry and Molecular Biophysics along with Makedonka Mitreva, PhD, Medicine of Medicine and Genetics, received a new four-year grant award from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, for their research entitled &＃8220;Innovative therapeutic strategies to support elimination of river blindness&＃8221;. August 11th, 2023 &＃8211; Natalie M. Niemi, PhD, Assistant Professor in the department of Biochemistry and Molecular Biophysics, received a new four-year grant award from Molecular and Cellular Biosciences Core Programs of the National Science Federation for her research entitled &＃8220;The role of protein phosphorylation in the mitochondrial matrix in determining mitophagic selectivity&＃8221;. August 11th, 2023 &＃8211; Natalie M. Niemi, PhD, Assistant Professor in the department of Biochemistry and Molecular Biophysics, received a new five-year MIRA grant award from National Institute of General Medical Sciences for her research entitled &＃8220;Delineating phosphorylation-mediated regulation of mitochondrial function&＃8221;. August 11th, 2023 &＃8211; Natalie M. Niemi, PhD, Assistant Professor in the department of Biochemistry and Molecular Biophysics, received a one-year grant award from the Washington University Digestive Disease Research Core Center (DDRCC), sponsored by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for her research entitled “Investigating mitochondrial protein phosphorylation in NAFLD and NASH”. Oct 1st 2022 – Alex Holehouse, assistant professor of biochemistry and molecular has received $380,000 in funding from the Human Frontiers Science Program (HFSP) to lead a three-year project titled &＃8220;Molecular determinants of evolutionary conservation in disordered protein regions&＃8221;. This project will integrate computational and experimental approaches to uncover who intrinsically disordered protein regions evolve. The proposal involves co-investigators Dr. Hyun Kate Lee (University of Toronto, CA) and Dr. Dolf Weijers (Wageningen University, NL). More Research Awards&＃8230; Home Member Directories Media and Newsletters News and Events Contact Us: Washington University School of Medicine Dept. of Biochemistry and Molecular Biophysics 660 S. Euclid Ave., Box 8231 St. Louis, MO 63110 Fax: 314-362-7183 Webmaster