新利18菲律宾|新利18备用

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Mecham Distinguished Lectureship CBP/MCB Joint Retreat Open Search Publications Recent Publications Circuit-based intervention corrects excessive dentate gyrus output in the fragile X mouse model (Links to an external site) eLife | February 12, 2024 Deng P-Y, Kumar A, Cavalli V, and Klyachko VA An orally available compound suppresses glucagon hypersecretion and normalizes hyperglycemia in type 1 diabetes (Links to an external site) JCI Insight | January 23, 2024 Asadi F, Gunawardana SC, Dolle RE, and Piston DW Identification of distinct vascular mural cell populations during zebrafish embryonic development (Links to an external site) Developmental Dynamics | December 19, 2023 Colijn S, Nambara M, Malin G, Sacchetti EA, and Stratman AN Browse publications by year 2024 Circuit-based intervention corrects excessive dentate gyrus output in the fragile X mouse model (Links to an external site) eLife | February 12, 2024 Deng P-Y, Kumar A, Cavalli V, and Klyachko VA An orally available compound suppresses glucagon hypersecretion and normalizes hyperglycemia in type 1 diabetes (Links to an external site) JCI Insight | January 23, 2024 Asadi F, Gunawardana SC, Dolle RE, and Piston DW 2023 Identification of distinct vascular mural cell populations during zebrafish embryonic development (Links to an external site) Developmental Dynamics | December 19, 2023 Colijn S, Nambara M, Malin G, Sacchetti EA, and Stratman AN Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2 (Links to an external site) Science Signaling | December 12, 2023 LaPak KM, Saeidi S, Bok I, Wamsley NT, Plutzer IB, Bhatt DP, Luo J, Ashrafi G, and Major MB The actin-bundling protein, PLS3, is part of the mechanoresponsive machinery that regulates osteoblast mineralization (Links to an external site) Frontiers in Cell and Developmental Biology | November 27, 2023 Chin SM, Unnold-Cofre C, Naismith T, and Jansen S Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation (Links to an external site) Journal of Cell Biology | November 21, 2023 Tiwari A, Hashemiaghdam A, Laramie MA, Maschi D, Haddad T, Stunault MI, Bergom C, Javaheri A, Klyachko V, and Ashrafi G Purification of modified mammalian actin isoforms for in vitro reconstitution assays (Links to an external site) European Journal of Cell Biology | December 2023 Kast DJ, and Jansen S IST1 regulates select recycling pathways (Links to an external site) Traffic | November 5, 2023 Clippinger AK, Naismith TV, Yoo W, Jansen S, Kast DJ, and Hanson PI Reducing mitochondrial mysteries (Links to an external site) Nature Chemical Biology | October 26, 2023 Guerra RM, and Pagliarini DJ A guide to studying mitochondria transfer (Links to an external site) Nature Cell Biology | October 18, 2023 Tiash S, Brestoff JR, and Crewe C Burning Fat to Fuel EVs (Links to an external site) Diabetes | October 20, 2023 Crewe C, and Brestoff JR Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses (Links to an external site) Molecular & Cellular Proteomics | November 1, 2023 Onken MD, Erdmann-Gilmore P, Zhang Q, Thapa K, King E, Kaltenbronn KM, Noda SE, Makepeace CM, Goldfarb D, Babur O, Townsend RR, and Blumer KJ PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy (Links to an external site) Nature Communications | October 13, 2023 Niemi NM, Serrano LR, Muehlbauer LK, Balnis CE, Wei L, Smith AJ, Kozul K-L, Forny M, Connor OM, Rashan EH, Shishkova E, Schueler KL, Keller MP, Attie AD, Friedman JR, Pagan JK, Coon JJ, and Pagliarini DJ Hem25p is required for mitochondrial IPP transport in fungi (Links to an external site) Nature Cell Biology | October 9, 2023 Tai J, Guerra RM, Rogers SW, Fang Z, Muehlbauer LK, Shishkova E, Overmyer KA, Coon JJ, and Pagliarini DJ Disrupting actin filaments enhances glucose-stimulated insulin secretion independent of the cortical actin cytoskeleton (Links to an external site) Journal of Biological Chemistry | October 10, 2023 Polino AJ, Ng XW, Rooks R, and Piston DW Mitochondrial proteome research: the road ahead (Links to an external site) Nature Reviews Molecular Cell Biology | September 29, 2023 Baker ZN, Forny P, and Pagliarini DJ Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC (Links to an external site) Molecular & Cellular Proteomics | September 14, 2023 Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le Q-T, Goldfarb D, and Major MB Molecular and cellular mechanisms of synaptopathies: emerging synaptic aging-related molecular pathways in neurological disorders (Links to an external site) Frontiers in Aging Neuroscience | August 10, 2023 Quinta HR, Ibanez L, Cruchaga C, and Maschi D Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells (Links to an external site) The Journal of Pharmacology and Experimental Therapeutics | August 1, 2023 Gao J, McClenaghan C, Matreyek KA, Grange DK, and Nichols CG Subunit gating resulting from individual protonation events in Kir2 channels (Links to an external site) Nature Communications | July 28, 2023 Maksaev G, Brundl-Jirout M, Stary-Weinzinger A, Zangerl-Plessl E-M, Lee S-J, and Nichols CG Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment (Links to an external site) DNA Repair | June 30, 2023 Tan K, Song Y, Xu M, and You Z Energetic Stress-Induced Metabolic Regulation by Extracellular Vesicles (Links to an external site) Comprehensive Physiology | June 26, 2023 Crewe C Mitochondrial uncouplers impair human sperm motility without altering ATP content (Links to an external site) Biology of Reproduction | June 9, 2023 Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, and Lishko PV Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis (Links to an external site) eLife | June 4, 2023 Mason DE, Goeckel M. Vega SL, Wu P-H, Johnson D, Heo S-J, Wirtz D, Burdick JA, Wood L, Chow B, Stratman AN, and Boerckel JD Scanning electron microscopy of human islet cilia (Links to an external site) PNAS | May 19, 2023 Polino AJ, Sviben S, Melena I, and Hughes JW Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses (Links to an external site) eLife | May 11, 2023 Malagon G, Myeong J, and Klyachko VA Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS (Links to an external site) EMBO Molecular Medicine | May 8, 2023 McClenaghan C, Mukadam MA, Roeglin J, Tryon RC, Grabner M, Dayal A, Meyer GA, and Nichols CG Isolation of Adipose Tissue Extracellular Vesicles (Links to an external site) Thermogenic Fat | April 20, 2023 Sabio JM, and Crewe C Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with KATP channel gain-of-function (Links to an external site) Function | April 18, 2023 Davis MJ, Castorena-Gonzalez JA, Jin Kim H, Li M, Remedi M, and Nichols CG Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function (Links to an external site) bioRxiv | April 13, 2023 Haoui M, Vergara C, and Lishko PV Oxidation Driven Reversal of PIP2-dependent Gating in GIRK2 Channels (Links to an external site) Function | April 10, 2023 Lee S-J, Maeda S, Gao J, and Nichols CG Untangling the connection between stress and metastatic breast cancer  (Links to an external site) Cancer Research | April 4, 2023 He X-Y, Ng D, Gao Y, Michalopoulou E, George S, Adrover J, Sun L, Albrengues J, Wan L, Han X, Vakoc CR, Van Aelst L, and Egeblad M. Blockade of TRPV channels by intracellular spermine (Links to an external site) Journal of General Physiology | March 13, 2023 Maksaev G, Yuan P, and Nichols CG p38MAPKa stromal reprogramming sensitizes metastatic breast cancer to immunotherapy (Links to an external site) Cancer Discovery | March 8, 2023 Faget DV, Luo X, Inkman MJ, Ren Q, Su X, Ding K, Waters MR, Raut GK, Pandey G, Dodhiawala PB, Ramalho-Oliveira R, Ye J, Cole T, Murali B, Zheleznyak A, Shokeen M, Weiss KR, Monahan JB, DeSelm CJ, Lee AV, Oesterreich S, Weilbaecher KN, Zhang J, DeNardo DG, and Stewart SA Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks (Links to an external site) Molecular Cell | February 16, 2023 Li S, Kong L, Meng Y, Cheng C, Lemacon DS, Yang Z, Tan K, Cheruiyot A, Lu Z, and You Z Aim18p and Aim46p are chalcone isomerase (CHI)-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae (Links to an external site) Journal of Biological Chemistry | February 3, 2023 Schmitz JM, Wolters JF, Murray NH, Guerra RM, Bingman CA, Hittinger CT, and Pagliarini DJ The NTPase activity of the double FYVE domain–containing protein 1 regulates lipid droplet metabolism (Links to an external site) Journal of Biological Chemistry | February 1, 2023 Ismail VA, Naismith T, and Kast DJ Coenzyme Q biochemistry and biosynthesis (Links to an external site) Trends in Biochemical Sciences | January 24, 2023 Guerra RM, and Pagliarini DJ Glucokinase Inhibition: A Novel Treatment for Diabetes? (Links to an external site) Diabetes | January 20, 2023 Remedi MS, and Nichols CG Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters (Links to an external site) Nature Communications | January 6, 2023 Matamoros M, Ng XW, Brettmann JB, Piston DW, and Nichols CG Personalized therapeutics for KATP-dependent pathologies (Links to an external site) Annual Review of Pharmacology and Toxicology | January 1, 2023 Nichols CG 2022 A unique high-output cardiac hypertrophy phenotype arising from low systemic vascular resistance in Cantu Syndrome (Links to an external site) Journal of the American Heart Association | December 14, 2022 Singh GK, McClenaghan C, Aggarwal M, Gu H, Remedi MS, Grange DK, and Nichols CG Rapid astrocyte-dependent facilitation amplifies multi-vesicular release in hippocampal synapses (Links to an external site) Cell Reports | December 13, 2022 Myeong J, and Klyachko V Genome-edited zebrafish model of ABCC8 loss-of-function disease (Links to an external site) Islets | December 2, 2022 Ikle JM, Tryon RC, Singareddy SS, York NW, Remedi MS, and Nichols CG Structure and functionality of a multimeric human COQ7:COQ9 complex (Links to an external site) Molecular Cell | November 17, 2022 Manicki M, Aydin H, Abriata LA, Overmyer KA, Guerra RM, Coon JJ, Dal Peraro M, Frost A, and Pagliarini DJ N-terminal acetylation and arginylation of actin determines the architecture and assembly rate of linear and branched actin networks (Links to an external site) Journal of Biological Chemistry | November 1, 2022 Chin SM, Hatano T, Sivashanmugam L, Suchenko A, Kashina AS, Balasubramanian MK, and Jansen S Small-molecule inhibition of the archetypal UbiB protein COQ8 (Links to an external site) Nature Chemical Biology | October 27, 2022 Murray NH, Asquith CR, Fang Z, Smith RW, Vasta JD, Zimprich CA, Corona CR, Robers MB, Bingman CA, and Pagliarini DJ KATP channels in lymphatic function (Links to an external site) American Journal of Physiology Cell Physiology | October 5, 2022 Davis MJ, Kim HJ, and Nichols CG Peristaltic pumps adapted for laminar flow experiments enhance in vitro modeling of vascular cell behavior (Links to an external site) Journal of Biological Chemistry | October 1, 2022 Abello J, Raghavan S, Yien YY, and Stratman AN Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors (Links to an external site) Nature Communications | August 5, 2022 Bhadra AK, Rau MJ, Daw JA, Fitzpatrick JAJ, Weihl CC, and True HL Context-dependent pro- and anti-resection roles of ZKSCAN3 in the regulation of fork processing during replication stress (Links to an external site) Journal of Biological Chemistry | August 1, 2022 Yang Z, Lemacon DS, Li S, Cheruiyot A, Kong L, Tan K, Cheng C, Turkay E, He D, and You Z 2-propylphenol allosterically modulates COQ8A to enhance ATPase activity (Links to an external site) ACS Chemical Biology | July 29, 2022 Murray NH, Lewis A, Pabon JPR, Gross ML, Henzler-Wildman K, and Pagliarini DJ Deficient caveolin-1 synthesis in adipocytes stimulates systemic insulin-independent glucose uptake via extracellular vesicles (Links to an external site) Diabetes | July 26, 2022 Crewe C, Chen S, Bu D, Gliniak CM, Wernstedt Asterholm I, Yu XX, Joffin N, de Souza CO, Funcke JB, Oh DY, Varlamov O, Robino JJ, Gordillo R, and Scherer PE Enabling hotspot detection and public health response to the COVID-19 pandemic (Links to an external site) Preventing Chronic Disease | June 30, 2022 Foraker R, Landman J, Lackey I, Haslam MD, Antes AL, and Goldfarb D Semiautomated analysis of an optical ATP indicator in neurons (Links to an external site) Neurophotonics | June 27, 2022 Dehkharghanian T, Hashemiaghdam A, and Ashrafi G The challenges of interrogating adipose tissue extracellular vesicle functions in physiology (Links to an external site) Communications Biology | June 14, 2022 Crewe C Stress response regulates cancer fibroblasts (Links to an external site) Nature Cell Biology | June 2, 2022 Faget DV, and Stewart SA Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling (Links to an external site) Journal of Biological Chemistry | June 1, 2022 Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, and Major MB Association of the receptor for activated C-kinase 1 (RACK1) with ribosomes in Plasmodium falciparum (Links to an external site) Journal of Biological Chemistry | June 1, 2022 Erath J, and Djuranovic S Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling (Links to an external site) Journal of Biological Chemistry | June 1, 2022 Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, and Major MB Defining mitochondrial protein functions through deep multiomic profiling (Links to an external site) Nature | May 25, 2022 Rensvold JW, Shishkova E, Sverchkov Y, Miller IJ, Cetinkaya A, Pyle A, Manicki M, Brademan DR, Alanay Y, Raiman J, Jochem A, Hutchins PD, Peters SR, Linke V, Overmyer KA, Salome AZ, Hebert AS, Vincent CE, Kwiecien NW, Rush MJP, Westphall MS, Craven M, Akarsu NA, Taylor RW, Coon JJ, and Pagliarini DJ FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells (Links to an external site) Cell Reports | May 17, 2022 Deng PY, Kumar A, Cavalli V, and Klyachko VA The microenvironment-a general hypothesis on the homeostatic function of extracellular vesicles (Links to an external site) FASEB BioAdvances | May 1, 2022 Stratman AN, Crewe C, and Stahl PD Caught in a web: emerging roles of neutrophil extracellular traps in cancer (Links to an external site) Annual Reviews of Cancer Biology | April 1, 2022 He X-Y, Ng D, and Egeblad M. High-throughput methodology to identify CRISPR-generated Danio rerio mutants using fragment analysis with unmodified PCR products (Links to an external site) Developmental Biology | April 1, 2022 Colijn S, Yin Y, and Stratman AN ATP-sensitive potassium channels in hyperinsulinism and type 2 diabetes: Inconvenient paradox or new paradigm? (Links to an external site) Diabetes | February 23, 2022 Nichols CG, York NW, and Remedi MS Modulation of miRISC-mediated gene silencing in eukaryotes (Links to an external site) Frontiers in Molecular Biosciences | February 14, 2022 Jungers CF, and Djuranovic S The GTPase activity of the Double FYVE Domain Containing Protein I (DFCPI) regulates liquid droplet metabolism (Links to an external site) bioRxiv | February 10, 2022 Ismail VA, Naismith T, and Kast DJ Isolation of cardiac and vascular smooth muscle cells from adult, juvenile, larval and embryonic zebrafish for electrophysiological studies (Links to an external site) Journal of Visualized Experiments | February 9, 2022 Singareddy SS, McClenaghan C, Roessler HI, Tryon R, and Nichols CG Gene expression predicts dormant metastatic breast cancer cell phenotype (Links to an external site) Breast Cancer Research | January 29, 2022 Ren Q, Khoo WH, Corr AP, Phan TG, Croucher PI, and Stewart SA Bridging personal and population in excitability diseases: Will studies of rare diseases bring generalizable mechanisms from monogenic channelopathies? (Links to an external site) Function | January 4, 2022 Nichols CG, and McClenaghan C Oncogenic Gq/11 signaling acutely drives and chronically sustains metabolic reprogramming in uveal melanoma (Links to an external site) Journal of Biological Chemistry | January 1, 2022 Onken MD, Noda SE, Kaltenbronn KM, Frankfater C, Makepeace CM, Fettig N, Piggott KD, Custer PL, Ippolito JE, and Blumer KJ Research Publications Laboratories Centers Entrepreneurship Resources Department of Cell Biology & PhysiologyWashington University School of Medicine660 S. 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