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Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Daniel Kerschensteiner Janet and Bernard Becker Professor of Ophthalmology, Professor of Ophthalmology and Visual Sciences, Vice Chair - Research Division, Professor of Biomedical Engineering, Professor of Neuroscience Department of Ophthalmology and Visual SciencesRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Developmental, Regenerative and Stem Cell BiologyDBBS - Molecular Cell BiologyDBBS - NeurosciencesHope Center for Neurological Disorders  https://orcid.org/0000-0002-6794-9056 Willing to MentorAvailable to Mentor:PhD/MSTP Students 2175 Citations 1998 …2024 Research activity per year Overview Fingerprint Network Research output (73) Similar Profiles (6) Personal profile Research interestsWe would like to understand how neural circuits process information and to uncover the principles and mechanisms that guide their development. Our efforts concentrate on the retina, the first stage of visual processing, and its subcortical targets. We generate transgenic and viral tools to label and manipulate specific neurons in these circuits. We use light – the natural input to the visual system – to elicit signals with high precision and track signal transformations across successive neurons of the circuitry using patch-clamp and multi-electrode array recordings. In addition, we study the organization and processing of visual information at a subcellular level by two-photon imaging. We explore molecular mechanisms that regulate the plasticity and specificity of neuronal morphologies and synaptic connections in developing visual circuits. Thus, we hope to identify features of neural circuit architecture that perform particular computations and characterize how they arise during development. By interfering with the development and/or function of these features, we aim to identify the behavioral significance of specific retinal and subcortical computations. Lab Website MentoringThe Kerschensteiner lab is committed to providing a safe and inclusive environment for everyone regardless of race/ethnicity, nationality, ancestry, socioeconomic status, gender, gender identity, sexual orientation, ability status, and marital/parental status. We believe that science is enriched and enhanced by diverse perspectives and are excited to train scientists from all traditional and non-traditional backgrounds. Available to Mentor:PhD/MSTP Students Fingerprint Dive into the research topics where Daniel Kerschensteiner is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 6 Similar Profiles Retina Medicine & Life Sciences 100% Retinal Ganglion Cells Medicine & Life Sciences 67% Retinal Chemical Compounds 62% Amacrine Cells Medicine & Life Sciences 41% Synapses Medicine & Life Sciences 39% Dendrites Medicine & Life Sciences 30% Axons Medicine & Life Sciences 29% Neurons Medicine & Life Sciences 27% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 1998 2011 2012 2013 2015 2017 2018 2020 2022 2024 2024 54 Article 8 Review article 4 Chapter 4 Short survey 3 More 1 Comment/debate 1 Conference article 1 Editorial Research output per year Research output per year A pupillary contrast response in mice and humans: Neural mechanisms and visual functionsFitzpatrick, M. J., Krizan, J., Hsiang, J. C., Shen, N. & Kerschensteiner, D., 2024, (Accepted/In press) In: Neuron.Research output: Contribution to journal › Article › peer-review Pupil 100% Constriction 59% Pupillary Reflex 46% Light 43% Retinal Rod Photoreceptor Cells 40% Distributed feature representations of natural stimuli across parallel retinal pathwaysHsiang, J. C., Shen, N., Soto, F. & Kerschensteiner, D., Dec 2024, In: Nature communications. 15, 1, 1920.Research output: Contribution to journal › Article › peer-review Open Access Retinal 100% stimuli 80% Block Like Crystal 58% cells 46% axons 36% Mapping the Retina onto the BrainKerschensteiner, D. & Feller, M. B., Feb 2024, In: Cold Spring Harbor perspectives in biology. 16, 2, a041512.Research output: Contribution to journal › Article › peer-review Open Access Retinal 100% Retinal Ganglion Cells 99% Retina 75% Brain 42% Axons 30% Predation without direction selectivityKrizan, J., Song, X., Fitzpatrick, M. J., Shen, N., Soto, F. & Kerschensteiner, D., Mar 19 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 12, e2317218121.Research output: Contribution to journal › Article › peer-review Open Access Direction compound 100% Superior Colliculi 99% Neurons 25% Ganglia 13% Reflex 12% 1 Scopus citations Subcellular pathways through VGluT3-expressing mouse amacrine cells provide locally tuned object-motion-selective signals in the retinaFriedrichsen, K., Hsiang, J. C., Lin, C. I., McCoy, L., Valkova, K., Kerschensteiner, D. & Morgan, J. L., Dec 2024, In: Nature communications. 15, 1, 2965.Research output: Contribution to journal › Article › peer-review Open Access Amacrine Cells 100% Retinal 85% retina 85% mice 77% Dendrites 76% View all 73 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. 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