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Holtzman, MD, and Xiaoying Chen, PhD, received the Jeffrey L. Morby Prize from Cure Alzheimer’s Fund in recognition of their groundbreaking 2023 paper on the role of T cells in neurodegeneration. Washington University School of Medicine in St. Louis faculty members David M. Holtzman, MD, the Barbara Burton and Reuben M. Morriss III Distinguished Professor of Neurology, and Xiaoying Chen, PhD, an instructor in neurology, were awarded the inaugural Jeffrey L. Morby Prize from Cure Alzheimer’s Fund, a nonprofit dedicated to supporting the most promising research to prevent, slow or reverse Alzheimer’s disease. The prize recognizes the senior and first authors of a recent scientific publication that transforms the fundamental understanding of Alzheimer’s disease and opens new paths to translate scientific results into effective ways to prevent, diagnose or treat the neurodegenerative condition. Holtzman and Chen as well as their co-authors were recognized for their groundbreaking 2023 paper, published in Nature, showing that T cells play a key role in neurodegeneration. Studying mice with Alzheimer’s-like damage in their brains, the researchers discovered that microglia, the brain’s resident immune cells, recruit T cells into the brain, where they contribute to neurodegeneration. Most of the cellular damage could be avoided by blocking the T cells’ entry or activation. The findings suggest potential new ways to approach treating Alzheimer’s disease. Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on Pinterest (Opens in new window)Click to share on LinkedIn (Opens in new window) Media Contact Tamara SchneiderSenior Medical Science [email protected] Related Editors' Picks June 6, 2024 Uncovering ‘the basis of humanity’ one puzzle at a timeMD/PhD student creates crosswords for major newspapers.Medical Campus & Community, Profiles May 30, 2024 Risk of death from COVID-19 lessens, but infection still can cause issues 3 years laterStudy also shows that patients hospitalized within 30 days after infection face 29% higher death risk in 3rd year compared with those not infected.News Release May 17, 2024 Repeat COVID-19 vaccinations elicit antibodies that neutralize variants, other virusesResponse to updated vaccine is shaped by earlier vaccines yet generates broadly neutralizing antibodies.News Release Directories Maps &＃038; Directions Calendars Contact Giving Follow us on Facebook Follow us on Twitter Follow us on Instagram Subscribe to us on YouTube Follow us on LinkedIn Follow us on TikTok Washington University School of Medicine 660 S. 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