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Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Andrew Yoo Professor of Developmental Biology Department of Developmental BiologyRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Developmental, Regenerative and Stem Cell BiologyDBBS - Molecular Genetics and GenomicsDBBS - NeurosciencesInstitute of Clinical and Translational Sciences (ICTS)Center of Regenerative MedicineHope Center for Neurological Disorders  https://orcid.org/0000-0002-0304-3247 Willing to MentorAvailable to Mentor:PhD/MSTP Students 3494 Citations 1993 …2024 Research activity per year Overview Fingerprint Network Research output (43) Similar Profiles (6) Personal profile Research interestsThe general goal of my research is to understand molecular mechanisms underlying the specification of cell types and developing methods to alter the fates of cells in vitro and in vivo. We recently discovered that small RNA molecules, microRNAs, could promote generation of post-mitotic neurons by demonstrating that expression of neuron-specific microRNAs and neural factors in non-neuronal cell types could directly reprogram their cell fates into functional neurons. We currently aim to 1) develop tissue culture models of neurological diseases using patient-specific neurons and to study cell autonomous properties associated with disease states in induced neurons, and 2) to identify molecular mechanisms underlying the neurogenic activity of neuron-specific microRNAs. We will use multiple interdisciplinary approaches (molecular genetics, genomics and biochemistry) to delineate how these microRNAs promote neuronal fates. Lab Website Available to Mentor:PhD/MSTP Students Fingerprint Dive into the research topics where Andrew Yoo is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 6 Similar Profiles MicroRNAs Medicine & Life Sciences 100% Neurons Medicine & Life Sciences 87% Fibroblasts Medicine & Life Sciences 63% Huntington Disease Medicine & Life Sciences 39% Corpus Striatum Medicine & Life Sciences 34% Chromatin Medicine & Life Sciences 27% Transcription Factors Medicine & Life Sciences 22% Chromatin Assembly and Disassembly Medicine & Life Sciences 22% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 1993 2009 2013 2015 2018 2020 2021 2024 30 Article 4 Review article 3 Chapter 2 Comment/debate 4 More 2 Short survey 1 Editorial 1 Letter Research output per year Research output per year Striatal neuronal models of Huntington's disease via direct conversion: Modeling age-dependent disease phenotypesOh, Y. M., Lee, S. W. & Yoo, A. S., Jan 1 2024, Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics. Elsevier, p. 411-425 15 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review Huntington Disease 100% Corpus Striatum 87% Neurons 55% Phenotype 54% MicroRNAs 32% Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegenerationOh, Y. M., Lee, S. W. & Yoo, A. S., 2023, In: Autophagy. 19, 9, p. 2613-2615 3 p.Research output: Contribution to journal › Article › peer-review Huntington Disease 100% Autophagy 86% MicroRNAs 75% Neurons 38% STAT3 Transcription Factor 32% 5 Scopus citations Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagyOh, Y. M., Lee, S. W., Kim, W. K., Chen, S., Church, V. A., Cates, K., Li, T., Zhang, B., Dolle, R. E., Dahiya, S., Pak, S. C., Silverman, G. A., Perlmutter, D. H. & Yoo, A. S., Nov 2022, In: Nature neuroscience. 25, 11, p. 1420-1433 14 p.Research output: Contribution to journal › Article › peer-review Open Access Huntington Disease 100% Corpus Striatum 87% Autophagy 86% Disease Progression 71% Neurons 55% 33 Scopus citations Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neuronsCapano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J. S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., Bateman, R. J., Houlden, H., Morimoto, R. I., Holtzman, D. M., Duff, K. E. & Yoo, A. S., Jun 2 2022, In: Cell Stem Cell. 29, 6, p. 918-932.e8Research output: Contribution to journal › Article › peer-review Open Access Protein Isoforms 100% Neurons 76% Tauopathies 67% MicroRNAs 41% Brain 36% 19 Scopus citations Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAsCates, K., McCoy, M. J., Kwon, J. S., Liu, Y., Abernathy, D. G., Zhang, B., Liu, S., Gontarz, P., Kim, W. K., Chen, S., Kong, W., Ho, J. N., Burbach, K. F., Gabel, H. W., Morris, S. A. & Yoo, A. S., Jan 7 2021, In: Cell Stem Cell. 28, 1, p. 127-140.e9Research output: Contribution to journal › Article › peer-review Open Access MicroRNAs 100% Fibroblasts 88% Neurons 73% Small Nuclear RNA 43% Motor Neurons 28% 33 Scopus citations View all 43 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply We use COOKIEs to help provide and enhance our service and tailor content. By continuing you agree to the use of COOKIEs About web accessibility Report vulnerability