新利18维护|18luck新利西部

Skip to content Skip to search Skip to footer Otolaryngology–Head & Neck Surgery Open Menu Back Close Menu Search for: Search Close Search AboutAbout History Our Mission Giving Contact Us Patient CarePatient Care Appointments &＃038; LocationsAppointments & Locations Virtual visits Patient safety For Referring Physicians Facial Plastic and Reconstructive Surgery Physicians Ear &＃038; HearingEar & Hearing Acoustic Neuroma Appointments &＃038; Locations Acoustic Neuroma Experts Auditory Brainstem Implants Our physicians Vestibular Cochlear Implant ProgramCochlear Implant Program Cochlear Implants Explained Rehabilitation &＃038; Research Audiology General OtolaryngologyGeneral Otolaryngology Common Complaints Sleep Disturbance Salivary Gland Disorders Head and Neck CancerHead and Neck Cancer Meet the Head and Neck Cancer Team World Class Multidisciplinary Care Surgical Innovation Head and Neck Cancer Survivorship Head and Neck Cancer Research International Physician Observer Program in Head &＃038; Neck Surgery Nose and Sinus DiseaseNose and Sinus Disease Rhinology Allergy Pediatric OtolaryngologyPediatric Otolaryngology Patient Forms &＃038; Information Sleep Voice &＃038; AirwayVoice & Airway Voice &＃038; Airway Team What our patients say Skull base surgery Specialties EducationEducation Residency ProgramsResidency Programs A Taste of WashU ENT Clinical Residency Physician-Scientist Training ProgramPhysician-Scientist Training Program Physician-Scientist Supplemental Resident Quality of Life Current Residents Recent Residency Graduates Applying &＃038; InterviewingApplying & Interviewing Information for Residency Candidates Fellowship ProgramsFellowship Programs Advanced Head &＃038; Neck Surgical Oncology and Microvascular ReconstructionAdvanced Head & Neck Surgical Oncology and Microvascular Reconstruction Physician Observations Neurotology Facial Plastic &＃038; Reconstructive Surgery Pediatric Otolaryngology Medical StudentsMedical Students Predoctoral Training Program Diversity sub-internship Courses Research Opportunities Surgical Simulation Lab Program in Audiology and Communication Sciences Learning Environment Alumni ResearchResearch LaboratoriesLaboratories Puram LabPuram Lab Puram Lab Opportunities Puram Lab Team Puram Lab News Puram Lab Publications Puram Lab Research Projects Kim LabKim Lab Kim Lab Opportunities Kim Lab Team Kim Lab Research Projects Kim Lab Publications Kim Lab News Firszt LabFirszt Lab Firszt Lab Contacts Firszt Lab Team Sheets Lab Outcomes Research People News &＃038; EventsNews & Events Clinical Research Education and Statistics Training (CREST) Workshop 2024 Midwest Otolaryngology Simulation Training Special EventsSpecial Events Senturia Lectureship Spector Lectureship Shepard Lecture Ogura Lectureship Calendar Latest NewsLatest News Newsletter Inclusion &＃038; Diversity Open Search Sheets Lab Lavinia Sheets, PhDAssistant ProfessorOtolaryngology—Head &＃038; Neck Surgery Email: [email protected] Hair cells are the sensory receptors of sound, motion, and spatial orientation. Exposure to excessively loud noise or certain drugs can permanently damage hair cells and their connections to nerve fibers. My lab investigates the cellular mechanisms of noise-induced and chemical hair-cell damage using zebrafish as a model for human hearing and deafness. Overview Hair cells are the sensory receptors of sound, motion, and spatial orientation. Overexposure to sound initiates a series of molecular events in hair cells that lead to various pathologies. Our research interests are to understand how specific pathological changes occur in hair cells exposed to noise by defining the dynamic cellular processes that lead to hair-cell synapse loss and hair-cell death. We investigate these questions using zebrafish as a model for human hearing and deafness. Caption describing what is being shown in this image. Our research — in depth Sensory hair cells—the sensory receptors of the auditory system—must convey a wide range of sound intensities (from a whisper to a thunderclap) and do so both reliably and inexhaustibly. This is accomplished by exquisitely sensitive synaptic connections between hair cells and nerve fibers that carry sensory information to the brain. The sensitivity of hair-cell synaptic connections comes at a price—they are vulnerable to damage when exposed to intense noise. Recent research indicates prolonged exposure to moderately loud noise, such as a rock concert or a stadium football game, damages hair-cell synaptic connections, resulting in hair-cell synapse loss and permanent deficits in auditory acuity. Zebrafish are a well-established model for human hearing and deafness and provide an advantageous system to investigate mechanisms of noise-induced hair-cell damage. The zebrafish lateral-line organ—a sensory organ used to detect the movement of water—contains superficially localized hair cells that are relatively easy to manipulate pharmacologically or genetically, and are optically accessible in whole larval fish. We can thereby manipulate cellular pathways in hair cells and examine progressive hair-cell damage in a live, intact preparation.  In addition, the Sheets lab takes advantage of the zebrafish’s ability to regenerate complex tissues following damage, including hair-cells and their innervating nerve fibers. Caption describing what is being shown in this image. Current projects Defining the cellular pathways that bring about hair-cell synapse loss and hair cell death following damaging noise exposures. Identifying biological pathways that promote nerve regeneration and hair-cell reinnervation with the goal of providing information toward clinical regenerative therapies.Identifying novel protectants against cisplatin-induced neurotoxicity with the goal of protecting auditory nerve fibers from damage during cisplatin-based chemotherapy. View publications » Caption describing what is being shown in this image. Support NIH Research Project Grant (R01DC016066) Roles of the Synapse in Hair-Cell Pathology • 07/01/17-06/30/22 The goal of this research is to understand how pathological changes at the hair-cell synapse stemming from excessive noise exposure ultimately contribute to sensorineural hearing loss. Action on Hearing Loss International Grant Identifying Novel Therapies to Promote Nerve Regeneration and Hair-Cell Nerve Reinnervation • 03/01/17 – 3/01/20 The goal of this project is to identify compounds that may promote cochlear nerve regeneration and hair-cell reinnervation by performing a large-scale drug screen for modulators of lateral-line organ regeneration in zebrafish. Children&＃8217;s Discovery Institute Prevention of Sensory Pathology following Cisplatin Chemotherapy • 07/01/18 – 6/30/21 The goal of this project is to identify novel protectants against cisplatin-induced neurotoxicity by performing a large-scale drug screen in zebrafish. This screen will not only provide information toward pharmacological interventions that may protect auditory nerve fibers, but will also identify compounds that may protect against general cisplatin-induced sensory neuropathy. Our team Kyle Newton, PhD, Postdoctoral AssociateMelanie Holmgren, Research TechnicianAllison Saettele, Research TechnicianAngie Schrader, Research Specialist Caption describing what is being shown in this image. Contact us Dept. Otolaryngology, Campus Box 8115Washington Univ. School of Medicine660 S. Euclid Ave.St. Louis, MO [email protected] Physical Address CID BuildingRoom 2243 (lab), 2258 (office)4560 Clayton Ave.St. Louis, MO 63110 Research Laboratories Puram Lab Kim Lab Firszt Lab Sheets Lab Outcomes Research Department of OtolaryngologyWashington University School of Medicine660 South Euclid AvenueCampus Box 8115St. Louis, MO [email protected] Us Instagram Twitter YouTube Contacts Physician directory MyChart Appointments: 314-362-7509 Administrative office: 314-362-7395 Media assistance Careers Faculty Job Openings Staff Job Openings Team Resources AMiON (Call Schedule) Workday ©2024 Washington University in St. Louis