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World Report Hospitals AboutAbout Benefits of an Academic Medical Center Mission, Clinical Vision and Core ValuesMission, Clinical Vision and Core Values Diversity, Equity and Inclusion Clinical Trials No Surprises Medical Billing Employment Privacy Statement Terms of Use Open Search Clinical Trials Clinical trials are voluntary research studies in which new treatments—drugs, diagnostic procedures, vaccines, treatment procedures, and other therapies—are tested in people to see if they are safe and effective. Part of our mission as an academic medical center is to advance new research to benefit our patients. Washington University School of Medicine conducts over 1,000 clinical studies every year.  You may check the Study Search website for a listing of current trials. To participate in a clinical trial Investigators need volunteers to serve as research participates for every clinical study. You can learn more about this at the Volunteer for Health website. The Volunteer for Health (VFH) program is sponsored by Washington University School of Medicine to support patient-oriented research at the Washington University Medical Center.  By participating in a medical study, you can help improve the future of healthcare.  People of every ethnic group, with and without any medical condition, are needed. Another option is StudySearch which is an online listing of research studies that are seeking volunteers at Washington University School of Medicine.  Cancer clinical trials The Siteman Cancer Center offers many types of clinical trials or research protocols.  Visit their clinical trial directory to search the more than 350 active clinical trials. Common questions What is a clinical trial? A clinical trial is the last of a long process of testing a new drug, a new procedure, a new treatment or combination of treatments. Drug testing and development are very carefully regulated by the United States government via the Federal Drug Agency (FDA). The search for cures to medical conditions usually starts in a laboratory, where scientists test new ideas on tissue and other samples. This is Phase I. Then promising treatments are tested on animals (Phase II) to see if it has harmful side-effects. If the procedure or drug is not toxic and show real promise, it moves to Phase III where trials are conducted on volunteer patients with the disease in question to see if the drug or procedure is safe and effective. Last, after the drug is licensed and is available to all physicians, clinical trials may be conducted with volunteer patients to find additional uses of the treatment the drug. Clinical trials are also called clinical studies, research protocols or medical research. They often compare one drug against another to see which is more effective, or they will try the medicine or procedure in a specific demographic group, such as people over 65 or in women, in men with high blood pressure, etc. Visit clinicaltrials.gov to search the registry for current trials. Why would I want to participate? First, everyone benefits when medical science moves forward. Perhaps your participation in a trial will make a significant difference to the health of thousands of other people. Second, you may be helped personally by being part of a trial that tests a new compound or a new treatment that is not available to the general population. Although this requires more time invested from you, you also receive closer medical attention than if you were not participating in a trial. Usually your medical visits and procedures are at no cost; occasionally there is a trial payment fee given to the patient for participating. This is to compensate you for the extra time that may be required in additional office visits, or for you to complete required forms. Important points to remember Clinical trials are tests of medical treatments to see if they are safe and if they work.Before you agree to take part in a study, you must be given complete information about the study, including possible side-effects and benefits.You must sign a special agreement called &＃8220;Informed Consent&＃8221; before taking part in the study.You can leave the study at any time. Informed consent protects volunteers To help you decide if you want to be a volunteer in a study, FDA requires that you be given complete information about the study before you agree to take part. This is known as informed consent. FDA requires that volunteers be told: that the study involves research of an unproven drug or device the purpose of the researchhow long the study is expected to takewhat will go on in the study and which parts of the study are experimentalpossible risks or discomforts, possible benefitsother procedures or treatments that you might want to consider instead of the treatment being studiedthat FDA may inspect study records, but the records will be kept confidentialwhether any medical treatments are available if you are hurt, what those treatments are, where they can be found, and who will pay for the treatmentthe person to contact with questions about the study, your rights, and injuries related to researchbeing in the study is voluntary and you can quit at any time. Informed consent information should be written so you can understand it. If you don&＃8217;t, be sure to ask the doctor or other medical person to explain it. Make sure you understand all of it before you agree to be in the study. Before you can participate in the trial, you must sign the informed consent form, showing that you have been given this information and understand it. The informed consent form is NOT a contract and you can leave the study at any time, for any reason. Phases of drug development Phase I clinical trials: Researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects. Phase II clinical trials: The study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety. Phase III studies: The study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely. Phase IV studies are done after the drug or treatment has been marketed. These studies continue testing the study drug or treatment to collect information about their effect in various populations and any side effects associated with long-term use. About Benefits of an Academic Medical Center Mission, Clinical Vision and Core Values Clinical Trials No Surprises Medical Billing Employment Privacy Statement Terms of Use Sign up for updates! Get health-care news from Washington University Physicians in your inbox. Constant Contact (Right Sidebar) Email * If you are human, leave this field blank. Submit Created with Sketch. Washington University Physicians are the medical staff of Barnes-Jewish Hospital and St. Louis Children's Hospital. Washington University Physicians Facebook Twitter Instagram YouTube Resources FPP Intranet LinkedIn Terms of Use Privacy Statement No Surprises Medical Billing ©2024 Washington University in St. Louis