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Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Roberta Faccio Jerome J. Gilden, M.D. Endowed Distinguished Professorship in Orthopedic Surgery, Professor of Orthopedic Surgery, Professor of Cell Biology and Physiology Division of Basic ResearchRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Cancer BiologyDBBS - ImmunologyDBBS - Molecular Cell BiologyInstitute of Clinical and Translational Sciences (ICTS)Siteman Cancer Center  https://orcid.org/0000-0003-1639-2005 Willing to MentorAvailable to Mentor:PhD/MSTP Students 4994 Citations 1994 …2024 Research activity per year Overview Fingerprint Network Research output (80) Similar Profiles (12) Personal profile Research interestsExcessive bone loss in rheumatoid arthritis and some bone metastasis is mostly due to an abnormal activation of the immune system leading to stimulation of osteoclasts (OCs). Our goal is to discover common signaling molecules affecting the osteo-immune system and study their impact on normal and pathological bone loss. We have identified a novel role for the immunomodulatory protein PLC?2 as central mediator of RANKL-induced osteoclastogenesis, independent of PLC?1. OCs, the principal bone resorbing cells, develop from bone marrow macrophages primarily under the influence of two major regulators: M-CSF and RANKL, and less understood costimulatory factors that act via immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors on OC precursor cells. Our data indicate that targeted deletion of PLC?2 leads to an osteopetrotic phenotype due to defective OC recruitment and function. Thus, the interest of my lab is to 1) identify structural domains of PLC?2 required for OC differentiation and understand the mechanism leading to PLC?2 activation, but not PLC?1, in the bone resorbing cells; 2) examine the interaction of PLC?2 with element of the OC cytoskeleton and the avß3 integrin during bone resorption and study the role of PLC?2 in OC activation and bone erosion in vivo; 3) considering the importance of PLC?2 in regulation of B cell mediated immune responses and osteoclastogenesis, determine the relative PLC?2-dependent contribution of B and T cells in the development of inflammation and bone erosion in rheumatoid arthritis; and 4) study the role of the of PLC?2 in the progression of breast cancer induced bone metastases. These studies might unveil novel OC regulatory mechanisms and provide the basis for new antiresorptive therapies in the context of inflammatory bone loss and bone cancer metastases. Lab Website Available to Mentor:PhD/MSTP Students Fingerprint Dive into the research topics where Roberta Faccio is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 12 Similar Profiles Osteoclasts Medicine & Life Sciences 100% Bone and Bones Medicine & Life Sciences 42% Osteogenesis Medicine & Life Sciences 31% Integrins Medicine & Life Sciences 25% Bone Resorption Medicine & Life Sciences 17% Macrophage Colony-Stimulating Factor Medicine & Life Sciences 16% Neoplasms Medicine & Life Sciences 14% Osteolysis Medicine & Life Sciences 14% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 1994 2003 2006 2007 2008 2010 2011 2012 2013 2015 2016 2019 2020 2021 2024 69 Article 3 Review article 2 Chapter 2 Comment/debate 4 More 2 Editorial 1 Conference contribution 1 Short survey Research output per year Research output per year Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 InflammasomeKhanna, K., Yan, H., Mehra, M., Rohatgi, N., Mbalaviele, G., Mellins, E. D. & Faccio, R., Jan 2024, In: Arthritis and Rheumatology. 76, 1, p. 107-118 12 p.Research output: Contribution to journal › Article › peer-review Open Access Inflammasomes 100% Interleukin-1 83% Storm Syndrome 74% mouse transmembrane protein 178 61% Juvenile Arthritis 56% Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fatDavis, J. L., Pokhrel, N. K., Cox, L., Rohatgi, N., Faccio, R. & Veis, D. J., Dec 2022, In: Scientific reports. 12, 1, 4915.Research output: Contribution to journal › Article › peer-review Open Access Adipocytes 100% Knockout Mice 96% Fats 78% Bone and Bones 62% Genetic Recombination 60% 2 Scopus citations The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bonePal, S., Perrien, D. S., Yumoto, T., Faccio, R., Stoica, A., Adams, J., Coopersmith, C. M., Jones, R. M., Neale Weitzmann, M. & Pacifici, R., Jun 15 2022, In: Journal of Clinical Investigation. 132, 12, e157340.Research output: Contribution to journal › Article › peer-review Open Access Th1 Cells 100% Bone Development 95% Microbiota 85% Natural Killer Cells 80% Melanoma 71% 14 Scopus citations Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcomaDavis, J. L., Thaler, R., Cox, L., Ricci, B., Zannit, H. M., Wan, F., Faccio, R., Dudakovic, A., van Wijnen, A. J. & Veis, D. J., Jul 2021, In: PloS one. 16, 7 July, e0254426.Research output: Contribution to journal › Article › peer-review Open Access S100 Calcium-Binding Protein A4 100% Sarcoma 58% Phosphotransferases 47% Neoplasms 19% Staining and Labeling 10% 3 Scopus citations Effective Treatment of Established Bone Metastases Can Be Achieved by Combinatorial Osteoclast Blockade and Depletion of Granulocytic SubsetsCapietto, A. H., Lee, S., Clever, D., Eul, E., Ellis, H., Ma, C. X. & Faccio, R., Dec 2021, In: Cancer immunology research. 9, 12, p. 1400-1412 13 p.Research output: Contribution to journal › Article › peer-review Open Access Osteoclasts 100% Myeloid-Derived Suppressor Cells 64% Zoledronic Acid 63% Neoplasm Metastasis 59% Bone and Bones 57% 10 Scopus citations View all 80 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. 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