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Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Eric Galburt Professor of Biochemistry and Molecular Biophysics Department of Biochemistry & Molecular BiophysicsRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Biochemistry, Biophysics, and Structural BiologyDBBS - Molecular Microbiology and Microbial PathogenesisInstitute of Clinical and Translational Sciences (ICTS)  https://orcid.org/0000-0003-4314-3215 Willing to MentorAvailable to Mentor:PhD/MSTP Students 1267 Citations 19992024 Research activity per year Overview Fingerprint Network Research output (35) Similar Profiles (9) Personal profile Research interestsWe are interested in the biochemistry and biophysics of protein-DNA interactions. In particular, we strive to understand the physical mechanisms of transcription initiation and DNA repair. We use a variety of techniques to investigate the molecular interactions between RNA polymerases, DNA translocases, DNA helicases, and transcription factors that underlie essential processes in biology. Current work in the lab is focused on the following: The mechanisms and outcomes of gene regulation in Mycobacterium tuberculosis (Mtb)The activation of Mtb DNA helicases and their roles in different pathways of DNA repair.The mechanisms of basal transcription initiation in Eukaryotes.The biophysics of viral RNA compaction Lab WebsiteMentoringI believe in supporting all members of my laboratory, the program, the division, and the school. The scientific pursuit, today and tomorrow, depends on thoughtful and active student mentorship. This includes training in the scientific method itself, as well as the more technical aspects of research. I know from experience that different students often benefit from different kinds of support and try to adapt my mentoring style accordingly.

I recognize that systematic racism and sexism has resulted in a lack of diversity in scientific endeavors. Due to the systemic nature of the issue, the active engagement of all those placed in leadership roles within science is needed. Along these lines, I pledge to push the systems in which I participate including my lab, my department, my graduate program, and my university towards a more just and representative distribution of our broader community.Education activities and interestsCo-director, DBBS - Biochemistry, Biophysics, and Structural Biology ProgramCourse-master of Bio458 - Nucleic Acids and Protein Biosynthesis Available to Mentor:PhD/MSTP Students Fingerprint Dive into the research topics where Eric Galburt is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 9 Similar Profiles DNA-Directed RNA Polymerases Medicine & Life Sciences 100% Mycobacterium tuberculosis Medicine & Life Sciences 63% DNA Medicine & Life Sciences 57% RNA Polymerase II Medicine & Life Sciences 55% Kinetics Medicine & Life Sciences 33% DNA Helicases Medicine & Life Sciences 30% Transcription Initiation Site Medicine & Life Sciences 28% RNA Medicine & Life Sciences 26% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 1999 2000 2002 2009 2014 2015 2016 2017 2018 2019 2021 2022 2024 32 Article 1 Chapter 1 Short survey 1 Review article Research output per year Research output per year Mycobacterium tuberculosis Ku Stimulates Multi-round DNA Unwinding by UvrD1 MonomersChadda, A., Kozlov, A. G., Nguyen, B., Lohman, T. M. & Galburt, E. A., Jan 15 2024, In: Journal of Molecular Biology. 436, 2, 168367.Research output: Contribution to journal › Article › peer-review Open Access Mycobacterium tuberculosis 100% Ku Autoantigen 81% DNA 57% Oxidation-Reduction 49% DNA Repair 47% 2 Scopus citations High-throughput, fluorescent-aptamer-based measurements of steady-state transcription rates for the Mycobacterium tuberculosis RNA polymeraseJensen, D., Ruiz Manzano, A., Rector, M., Tomko, E. J., Record, M. T. & Galburt, E. A., Oct 27 2023, In: Nucleic acids research. 51, 19, p. E99Research output: Contribution to journal › Article › peer-review Open Access DNA-Directed RNA Polymerases 100% Mycobacterium tuberculosis 87% RNA 62% Gels 24% Fluorescence 24% Molecular dissection of RbpA-mediated regulation of fidaxomicin sensitivity in mycobacteriaPrusa, J., Zhu, D. X., Flynn, A. J., Jensen, D., Manzano, A. R., Galburt, E. A. & Stallings, C. L., Apr 1 2022, In: Journal of Biological Chemistry. 298, 4, 101752.Research output: Contribution to journal › Article › peer-review Open Access Fidaxomicin 100% Staphylococcal Protein A 55% Mycobacterium 51% Dissection 41% Carrier Proteins 40% 3 Scopus citations Mycobacterium tuberculosis DNA repair helicase UvrD1 is activated by redox-dependent dimerization via a 2B domain cysteineChadda, A., Jensen, D., Tomko, E. J., Manzano, A. R., Nguyen, B., Lohman, T. M. & Galburt, E. A., Feb 22 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 8, e2114501119.Research output: Contribution to journal › Article › peer-review Open Access DNA Helicases 100% Dimerization 81% Mycobacterium tuberculosis 69% Oxidation-Reduction 68% Cysteine 67% 6 Scopus citations Parallel path mechanisms lead to nonmonotonic force-velocity curves and an optimum load for molecular motor functionMallimadugula, U. L. & Galburt, E. A., Mar 2022, In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 105, 3, 034405.Research output: Contribution to journal › Article › peer-review Molecular Motor 100% Path 40% Energy Landscape 37% Curve 36% curves 32% View all 35 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply We use COOKIEs to help provide and enhance our service and tailor content. By continuing you agree to the use of COOKIEs About web accessibility Report vulnerability