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Skip to content Skip to search Skip to footer Otolaryngology–Head & Neck Surgery Open Menu Back Close Menu Search for: Search Close Search AboutAbout History Our Mission Giving Contact Us Patient CarePatient Care Appointments &＃038; LocationsAppointments & Locations Virtual visits Patient safety For Referring Physicians Facial Plastic and Reconstructive Surgery Physicians Ear &＃038; HearingEar & Hearing Acoustic Neuroma Appointments &＃038; Locations Acoustic Neuroma Experts Auditory Brainstem Implants Our physicians Vestibular Cochlear Implant ProgramCochlear Implant Program Cochlear Implants Explained Rehabilitation &＃038; Research Audiology General OtolaryngologyGeneral Otolaryngology Common Complaints Sleep Disturbance Salivary Gland Disorders Head and Neck CancerHead and Neck Cancer Meet the Head and Neck Cancer Team World Class Multidisciplinary Care Surgical Innovation Head and Neck Cancer Survivorship Head and Neck Cancer Research International Physician Observer Program in Head &＃038; Neck Surgery Nose and Sinus DiseaseNose and Sinus Disease Rhinology Allergy Pediatric OtolaryngologyPediatric Otolaryngology Patient Forms &＃038; Information Sleep Voice &＃038; AirwayVoice & Airway Voice &＃038; Airway Team What our patients say Skull base surgery Specialties EducationEducation Residency ProgramsResidency Programs A Taste of WashU ENT Clinical Residency Physician-Scientist Training ProgramPhysician-Scientist Training Program Physician-Scientist Supplemental Resident Quality of Life Current Residents Recent Residency Graduates Applying &＃038; InterviewingApplying & Interviewing Information for Residency Candidates Fellowship ProgramsFellowship Programs Advanced Head &＃038; Neck Surgical Oncology and Microvascular ReconstructionAdvanced Head & Neck Surgical Oncology and Microvascular Reconstruction Physician Observations Neurotology Facial Plastic &＃038; Reconstructive Surgery Pediatric Otolaryngology Medical StudentsMedical Students Predoctoral Training Program Diversity sub-internship Courses Research Opportunities Surgical Simulation Lab Program in Audiology and Communication Sciences Learning Environment Alumni ResearchResearch LaboratoriesLaboratories Puram LabPuram Lab Puram Lab Opportunities Puram Lab Team Puram Lab News Puram Lab Publications Puram Lab Research Projects Kim LabKim Lab Kim Lab Opportunities Kim Lab Team Kim Lab Research Projects Kim Lab Publications Kim Lab News Firszt LabFirszt Lab Firszt Lab Contacts Firszt Lab Team Sheets Lab Outcomes Research People News &＃038; EventsNews & Events Clinical Research Education and Statistics Training (CREST) Workshop 2024 Midwest Otolaryngology Simulation Training Special EventsSpecial Events Senturia Lectureship Spector Lectureship Shepard Lecture Ogura Lectureship Calendar Latest NewsLatest News Newsletter Inclusion &＃038; Diversity Open Search Puram Lab Research Projects Our lab is dedicated to understanding the mechanisms that underlie the growth, development, and spread of head and neck cancers and to determine how these mechanisms may be targeted to develop new diagnostics and therapeutics for this devastating disease. Please see our research vision for a broad overview of our overarching goals. Briefly, we aim to expand the field of head and neck oncology through several major lines of research: Characterize expression and epigenetic heterogeneity in head and neck cancer Using cutting edge single cell techniques, which our lab has pioneered, we will investigate diversity present at the level of diverse individual cells, including malignant, stromal, and immune subpopulations. Although we have begun the difficult work of studying heterogeneity in oral cavity tumors, other subsite of HNSCC as well as other pathologies could greatly benefit from these studies. Future work will extend to deep analyses of epigenetic heterogeneity to complement studies of expression heterogeneity. Develop in vitro and in vivo models to study head and neck cancer Despite substantial interest there are few typified and widely accepted models of head and neck cancer. With access to numerous cell lines, we will characterize existing models in new ways using a combination of mutational and expression-based profiling, thereby validating how well these models recapitulate human tumors and their diversity. However, we are interested in developing more sophisticated models of these human cancers through patient-derived xenografts (PDX) and potentially syngeneic models that may better allow the immune system and its influence in head and neck cancer to be more accurately studied. Define the pathways that drive head and neck cancer metastasis, treatment resistance, self-renewal, and immunotherapy response Our prior work has identified a role for a partial epithelial-to-mesenchymal program in head and neck tumors, specifically oral cavity head and neck squamous cell carcinoma. We will use this foundational work as a starting point and by leveraging standard genetic and biochemical techniques, study this pathway in greater detail including its role in tumor invasion and locoregional and distant metastasis. In the future, we will investigate additional pathways in head and neck cancer that may define drug resistance, self-renewal capabilities, and immunotherapy response. Translating findings into new diagnostics and therapeutics Due in part to Dr. Puram’s clinical interests, we are highly motivated and well positioned to translate findings from our lab into meaningful changes in patient care. Through large scale pathologic studies using ISH and IHC combined with cutting edge technologies such as multiplexed imaging, we can begin to characterize potential biomarkers in head and neck cancer, while simultaneously utilizing traditional tools in drug discovery to identify targets for novel therapeutics. Our ultimate goal is to move our findings into early pre-clinical and clinical trials that will ultimately dramatically influence the way we manage this challenging disease. Research Laboratories Puram Lab Kim Lab Firszt Lab Sheets Lab Outcomes Research Department of OtolaryngologyWashington University School of Medicine660 South Euclid AvenueCampus Box 8115St. Louis, MO [email protected] Us Instagram Twitter YouTube Contacts Physician directory MyChart Appointments: 314-362-7509 Administrative office: 314-362-7395 Media assistance Careers Faculty Job Openings Staff Job Openings Team Resources AMiON (Call Schedule) Workday ©2024 Washington University in St. Louis