18新利快乐彩|新利18安全码

Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Zhongsheng You Professor of Cell Biology and Physiology, Professor of Medicine Department of Cell Biology & PhysiologyRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Biochemistry, Biophysics, and Structural BiologyDBBS - Cancer BiologyDBBS - Molecular Cell BiologyDBBS - Molecular Genetics and GenomicsSiteman Cancer Center  https://orcid.org/0000-0002-9719-8791 Willing to MentorAvailable to Mentor:PhD/MSTP Students 2710 Citations 1997 …2024 Research activity per year Overview Fingerprint Network Research output (40) Similar Profiles (12) Personal profile Research interestsThe surveillance systems that safeguard the genome and the transcriptome ensure faithful transmission and expression of genetic information and determine the function and the fate of the cell. Defects in these systems are associated with cancer, aging and neurological disorders. Our laboratory is interested in understanding the molecular basis of the DNA and RNA surveillance systems and their relation to human diseases, especially cancer. Our work in DNA surveillance is focused on the cellular response to the most dangerous type of DNA damage, DNA double-strand breaks. This highly sophisticated DNA damage response suppresses cancer formation and is also an important target of cancer therapy. Our work has contributed to the understanding of a number of key biochemical processes such as ATM activation and DNA end resection in the DNA damage response. Currently, we are pursuing the following fundamental questions: 1. How do cells read the DNA damage signal and translate the signal into downstream checkpoint and repair responses? 2. How do cells maintain genome stability during DNA replication and gene expression? In the RNA surveillance area, we focus on the nonsense-mediated mRNA decay (NMD) pathway. NMD selectively eliminates aberrant transcripts harboring premature translation termination codons and also regulates the levels of many physiological mRNAs. NMD is an attractive target of therapeutic intervention for cancer and other genetic diseases (e.g., cystic fibrosis and Duchenne muscular dystrophy). Through a high-throughput drug screen using a novel reporter system, we have recently identified a group of cardiac glycosides such as ouabain and digoxin as potent inhibitors of NMD. Furthermore, we have discovered that intracellular calcium is a key regulator of NMD. Our current work is aimed at elucidating the mechanism and physiological significance of the calcium regulation of NMD. In addition, we are pursuing the potential connections between RNA surveillance and DNA surveillance pathways. We employ a powerful combination of experimental systems and tools, including human cell culture, Xenopus egg extracts, laser microirradiation, genetically encoded reporters and live cell imaging, to dissect the DNA and RNA surveillance systems—with the long-term goal of improving the treatment of cancer and other diseases. Lab Website MentoringWe believe that diversity and inclusion are key to scientific advancement and personal development, and we are committed to creating a stimulating and supportive environment for research and training.  Available to Mentor:PhD/MSTP Students Fingerprint Dive into the research topics where Zhongsheng You is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 12 Similar Profiles DNA Damage Medicine & Life Sciences 100% Double-Stranded DNA Breaks Medicine & Life Sciences 89% DNA Medicine & Life Sciences 67% DNA Replication Medicine & Life Sciences 47% Xenopus Medicine & Life Sciences 45% Nonsense Mediated mRNA Decay Medicine & Life Sciences 40% RNA Stability Medicine & Life Sciences 39% Chromatin Medicine & Life Sciences 39% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 1997 1999 2002 2007 2009 2010 2013 2015 2016 2017 2018 2019 2023 2024 36 Article 3 Review article 1 Chapter Research output per year Research output per year TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forksKong, L., Cheng, C., Cheruiyot, A., Yuan, J., Yang, Y., Hwang, S., Foust, D., Tsao, N., Wilkerson, E., Mosammaparast, N., Major, M. B., Piston, D. W., Li, S. & You, Z., Dec 2024, In: Nature communications. 15, 1, 4609.Research output: Contribution to journal › Article › peer-review Open Access forks 100% Cell Viability 77% genome 75% deoxyribonucleic acid 70% Dissociation 55% CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resectionJaiswal, R. K., Lei, K. H., Chastain, M., Wang, Y., Shiva, O., Li, S., You, Z., Chi, P. & Chai, W., Dec 2023, In: Nature communications. 14, 1, 7882.Research output: Contribution to journal › Article › peer-review Open Access forks 100% Phosphorylation 53% Aphidicolin 41% phosphorylation 40% Hydroxyurea 37% 1 Scopus citations Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironmentTan, K., Song, Y., Xu, M. & You, Z., Sep 2023, In: DNA Repair. 129, 103531.Research output: Contribution to journal › Article › peer-review Tumor Burden 100% Oncogenes 59% Carcinogenesis 48% Neoplasms 33% Myeloid-Derived Suppressor Cells 28% 1 Scopus citations Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forksLi, S., Kong, L., Meng, Y., Cheng, C., Lemacon, D. S., Yang, Z., Tan, K., Cheruiyot, A., Lu, Z. & You, Z., Feb 16 2023, In: Molecular cell. 83, 4, p. 556-573.e7Research output: Contribution to journal › Article › peer-review Open Access cyclic guanosine monophosphate-adenosine monophosphate 100% Genome 44% DNA 36% DNA Replication 33% Ion Channels 32% 10 Scopus citations The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recoveryLi, Y., Wang, F., Li, X., Wang, L., Yang, Z., You, Z. & Peng, A., 2023, In: eLife. 12, RP86976.Research output: Contribution to journal › Article › peer-review Open Access DNA Damage 100% Dissociation 81% Dephosphorylation 71% Protein 47% Cell Cycle 36% View all 40 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. 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