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Skip to content Skip to search Skip to footer Program in Physical Therapy Open Menu Back Close Menu Search for: Search Close Search EducationEducation Doctor of Physical TherapyDoctor of Physical Therapy Application &＃038; Admissions Eligibility &＃038; Prerequisites Tuition &＃038; Financial Assistance Educational Experience Student Activities Curriculum CAPTE Success Statistics Clinical Education Program Clinical Instructor Resources PhD in Movement SciencePhD in Movement Science Application &＃038; Admissions Curriculum &＃038; Degree Requirements Tuition &＃038; Financial Assistance Current PhD Students PhD Alumni Steering Committee Dual DPT-PhD Postdoctoral Research FellowshipPostdoctoral Research Fellowship Application &＃038; Admissions Current Postdoctoral Research Scholars Financial Assistance Clinical Residency in Orthopaedics Clinical Residency in Women’s HealthClinical Residency in Women’s Health Application &＃038; Admissions AlumniAlumni Open Positions The Next 75 Years WUPT 75th Anniversary Celebration Movement System Impairment Syndromes CoursesMovement System Impairment Syndromes Courses Movement System Impairment (MSI) Resources Continuing Education for Clinical Instructors (CEUs)Continuing Education for Clinical Instructors (CEUs) Research Seminars &＃038; Recordings Schedule a Student Visit Patient CarePatient Care LocationsLocations Central West End Danforth Campus O&＃8217;Fallon Our Providers Our ServicesOur Services Musculoskeletal Rehabilitation Neuromuscular Rehabilitation Multidisciplinary Services Women’s &＃038; Men’s Pelvic Rehabilitation Pre- &＃038; Post-Surgical Rehabilitation Sports Injury &＃038; Performance Programs Specialty Techniques Vestibular and Concussion Rehabilitation Specialty Services and Programs Lymphedema Management Spinal Cord Injury Rehabilitation Cerebral Palsy Rehabilitation Wheelchair Seating and Positioning Clinic Aphasia Treatment Stroke/CVA Rehabilitation Dysphagia Treatment Social Work/Clinical Case Management Traumatic Brain Injury Rehabilitation Return to Driving Running Clinic Rehabilitation of the Performing Artist LSVT Loud Injury Prevention Programs Parkinson’s Disease Rehabilitation ASTYM Obesity Management dorsaVi VitalStim Therapy Telehealth Billing &＃038; Insurance Patient Testimonials ResearchResearch Our Research AreasOur Research Areas Foot &＃038; Ankle Injury &＃038; Recovery Hardware &＃038; Software Design for Rehabilitation Research Integrative Muscle Physiology Exercise and Cardio-Metabolic Health Movement &＃038; Musculoskeletal Problems in Diabetes Movement &＃038; Neurodegenerative Disease Neural Control of Movement Following Neurological Injury Neural Plasticity and Sensorimotor Integration Nutrition &＃038; Exercise Science Prevention, Rehabilitation &＃038; Maintenance in Musculoskeletal Conditions Physical Activity &＃038; Fitness Rehabilitation Research for Orthopaedic Conditions Stroke Recovery, Rehabilitation, and AccelerometryStroke Recovery, Rehabilitation, and Accelerometry For Lab Members Orthopaedic Biomechanics Accelerometry Movement Science Research Center Research Training Programs Clinical Trials Recent Publications Faculty &＃038; StaffFaculty &＃038; Staff Faculty Staff Clinical Providers Faculty Emeritus Open Faculty Positions DiversityDiversity PTID City Faces Recruitment Organizations &＃038; Student Groups Diversity, Equity, and Inclusion Resources Calendar AboutAbout Annual ReportAnnual Report 2019 Annual Report – Welcome2019 Annual Report – Welcome 2019 Annual Report – Education 2019 Annual Report – Clinical Practice 2019 Annual Report – Research 2019 Annual Report – Community Explore the Program in Physical Therapy Moving Ahead ContactContact Maps &＃038; Directions Schedule a Student Visit Seminar Series Invitation Request Work at WashU PT WUSM Bike Run Walk Club WUPT at 2024 Combined Sections Meeting Open Search Integrative Muscle Physiology We focus on understanding how changes at the cellular level in skeletal muscle affect muscle structure and function, and, in turn, how pathological changes in muscle affect cellular processes. Follow @lab_meyer At any given time, muscle tissue houses 5-10 distinct populations of cells, all of which communicate with each other and with their environment to regulate homeostasis and ensure proper muscle function. We know that when something goes awry, as in injury or disease, this communication gets interrupted or misdirected, and cells, such as fibroblasts and adipose progenitors, respond inappropriately by replacing healthy muscle tissue with connective tissue and fat. Yet we don’t fully understand the “language” of these cells, and this keeps us from being able to fully restore cellular interaction and tissue function in many pathologies. Our main projects are focused on the interaction between muscle and fat. Though much less studied than its “pathological sibling”, fibrosis, the formation of fat in and around muscle is equally prevalent across myopathies. Our research investigates fat’s effect on muscle function and how that effect is regulated at cellular and tissue levels. Current Lab Members Faculty Investigators Gretchen A. Meyer, PhD [Profile ] Staff and Student Members Jeremie Ferey, PhDLab Manager Jake ParsonPh.D. Student, Movement Science Chang GuiPh.D. Student, Biomedical Engineering Dakota KammPh.D. Student, Movement Science Karen ShenResearch Technician Cameron SwickDPT Student Current Research Studies The functional consequences of fat accumulation in muscle Decellularized muscle was stained with BODIPY, imaged with confocal microscopy and digitally reconstructed to generate this 3-D map of intramuscular fat. The accumulation of adipocytes within skeletal muscle is a nearly ubiquitous feature of muscle pathology – associated with conditions as diverse as aging, diabetes and tendon injury.  Though this fat accumulation is frequently associated with poor muscle strength in humans, a direct link has not been established due to systemic disease pressures that simultaneously affect muscle cells.  Recently, we have developed methodology for high-resolution mapping of intramuscular adipocytes in mouse muscle that we are using in conjunction with precision ex-vivo analysis of muscle contractile performance to define the direct effect of fat accumulation on muscle function.  Ongoing work in this area is investigating the effect of fat accumulation on hypertrophic signaling and the potential for dynamic forces (resistance exercise) to reverse this pathology.Check out https://pubmed.ncbi.nlm.nih.gov/32358797 The role of fat phenotype in fat-muscle cross-talk A transplanted graft of brown fat next to the supraspinatus muscle of the rotator cuff stained for perilipin (green) and UCP1 (red). The way we think about the function of fat in the body has changed dramatically over the past 10 years.  Fat is now recognized as one of the  most important endocrine regulators of body physiology – affecting a diversity of cells from neurons to osteoblasts.  However, despite the close proximity of muscle and fat (specifically inter-muscular adipose tissue – IMAT), we know very little about how these tissues might signal each other locally.  To explore this important question, we have developed an inter-muscular fat transplant model in the mouse where we can alter fat phenotype and genotype to study the factors that influence fat-muscle cross-talk.  Ongoing work on this project is exploring the role of brown and browned-beige fat signaling on muscle degeneration and regeneration in the rotator cuff.  It is our hope that defining these interactions will lead to fat-targeted therapies in rotator cuff tears where excessive accumulation of beige fat is impeding muscle functional recovery.Check out: https://www.ncbi.nlm.nih.gov/pubmed/?term=31042310 The cellular basis for poor muscle performance in diabetic peripheral neuropathy Histological image of a biopsy from an individual with diabetic peripheral neuropathy demonstrating fat infiltration (white circles). The accumulation of intramuscular fat is dramatic in diabetic peripheral neuropathy – replacing as much as 90% of the volume of muscles of the foot and calf.  To better understand the interaction between these intramuscular adipocytes and neighboring muscle fibers in humans, we are obtaining biopsies from participants undergoing amputation, separating the muscle and fat components and isolating progenitor cells.  Using these cells we can generate patient-specific co-culture models to study paracrine secreted factors from intramuscular fat and how those signals regulate myogenesis.Check out: https://pubmed.ncbi.nlm.nih.gov/32059624/ Guiding cell-based therapies to prevent fibrosis An APC immunostained for actin (green) and YAP (red). Defined actin stress fibers and nuclear YAP localization are typical of APCs grown on stiff substrates. These cells secrete more connective tissue matrix and exhibit signs of switching to a pro-fibrotic myofibroblast phenotype. Post-transitional control of EC-Coupling We are embarking on a new project to understand how EC-coupling is regulated by post transitional modifications. We have evidence that acetyltransferases p300/CBP are critical for muscle contraction, but the mechanism has yet to be determined. Check out http://pubmed.ncbi.nih.gov/31898871/. Our preliminary data support post-translational acetylation of protein(s) involved in EC-coupling can be tested in isolation to prove this and further hone the mechanism. You could be the one to figure it out! Apply to a post-doc with us today! Research Our Research Areas Biostatistics, Evidence, and Research Design Foot &＃038; Ankle Injury &＃038; Recovery Integrative Muscle Physiology Movement &＃038; Neurodegenerative Disease Neural Control of Movement Following Neurological Injury Neural Plasticity and Sensorimotor Integration Orthopaedic Biomechanics Prevention, Rehabilitation &＃038; Maintenance in Musculoskeletal Conditions Rehabilitation Research for Orthopaedic Conditions Shoulder Biomechanics and Rehabilitation Stroke Recovery, Rehabilitation, and Accelerometry Tendon Rehabilitation Lab Movement Science Research Center Research Training Programs Clinical Trials Recent Publications Program in Physical TherapyMailing Address:Campus Box 8502, 4444 Forest Park Ave., Suite 1101St. Louis, MO 63108-2212314-286-1400Contact us Facebook Instagram Twitter YouTube For Patients Central West End &＃8211; @4240 4240 Duncan Ave., Suite 120 St. Louis, MO 63110 Central West End &＃8211; 4444 4444 Forest Park Ave., Suite 1210 St. Louis, MO 63108-2212 For patient appointments, call 314-286-1940   O&＃8217;Fallon 1 Progress Point Parkway O&＃8217;Fallon, MO 63368 Danforth Campus Zetcher House 6614 Shepley Dr., Suite 1051 Clayton, MO 63105   Resources Alumni Disclosures Maps & Directions ©2024 Washington University in St. Louis