新利18刷流水|18.luck新利

Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Megan Baldridge Associate Professor of Medicine, Associate Professor of Molecular Microbiology Division of Infectious DiseasesRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Computational and Systems BiologyDBBS - ImmunologyDBBS - Molecular Genetics and GenomicsDBBS - Molecular Microbiology and Microbial PathogenesisInstitute for Public HealthInstitute of Clinical and Translational Sciences (ICTS)Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)Edison Family Center for Genome Sciences & Systems Biology  https://orcid.org/0000-0002-7030-6131 Willing to MentorAvailable to Mentor:PhD/MSTP Students 6106 Citations 20062024 Research activity per year Overview Fingerprint Network Research output (86) Similar Profiles (12) Personal profile Research interestsI am broadly interested in the complicated interplay between three important factors: commensal microbes, the host immune system, and viral and bacterial pathogens. Previous work has involved characterization of the intestinal commensal microbiota and interrogation of its role in regulation of both enteric viral infection and the host immune system. The coordination of next-generation sequencing efforts with in vivo infections and treatments in mouse models makes the exploration of transkingdom interactions possible. Moving forward, I will be exploring inflammation in the intestine induced by commensal bacteria and by pathogens, and the signaling pathways and transcription factors that regulate it. I will also be identifying the specific commensal bacteria necessary and sufficient to enhance and regulate viral infection in the intestine, and studying viral adaptation strategies to take advantage of commensal microbes and to infect at alternate host sites. Lab Website MentoringAs a principal investigator, I strive to make my laboratory a welcoming and supportive environment for individuals of diverse cultural, racial, and ethnic backgrounds, and inclusive for members with a diversity of professional experience, religious and political beliefs, sexual orientations and ages. With an intentional focus on recruiting talented staff and trainees with varying backgrounds, I have been fortunate to bring together individuals with an array of different perspectives, opinions, and ideas, allowing us as a team to find innovative solutions to complex biological problems. While as a mentor, I am always seeking how to best support and motivate individual trainees, I have come to recognize that careful listening and providing as much empathetic understanding as I can is often the key to helping trainees feel included and encouraged. Serving as a mentor for trainees from underrepresented groups has offered me important opportunities to grow, including assessing my own implicit biases and assessing what I have to offer and where students would benefit from other sources of support or mentorship. I have previously and continue to seek out educational opportunities related to both mentoring and diversity and inclusion considerations, and have participated in formal mentoring workshops in 2019 and 2021, as well as in a four-part course offered by Washington University entitled “Diversity & Inclusion: Awareness, Understanding, Commitment, Action” in 2019.
 Beyond my activities to improve my mentorship of individuals within my laboratory, I also seek to build a diverse and inclusive community at Washington University. As part of the Admissions Committee and now as a Co-Director for the Molecular Microbiology and Microbial Pathogenesis program, I have sought to both recruit a diverse range of students to our program as well as strongly support them during their training, and continue to work with various committees throughout the university to achieve a diverse and inclusive community of trainees. I recognize the importance of focused efforts at the individual, laboratory, and university levels to continue to enhance access to educational opportunities and supportive mentoring for our trainees from underrepresented backgrounds, and will continue to prioritize activities related to this ultimate goal. Available to Mentor:PhD/MSTP Students Fingerprint Dive into the research topics where Megan Baldridge is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 12 Similar Profiles Norovirus Medicine & Life Sciences 100% Microbiota Medicine & Life Sciences 71% Interferons Medicine & Life Sciences 56% Caliciviridae Infections Medicine & Life Sciences 52% Gastrointestinal Microbiome Medicine & Life Sciences 42% Enterovirus Medicine & Life Sciences 34% Virus Diseases Medicine & Life Sciences 31% Infections Medicine & Life Sciences 30% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 2006 2019 2021 2022 2023 2024 58 Article 16 Review article 5 Comment/debate 3 Letter 4 More 2 Chapter 1 Editorial 1 Short survey Research output per year Research output per year A new piece of the microbiota pie: Mining ‘omics for DNA inversion statesCampbell, D. E. & Baldridge, M. T., Mar 13 2024, In: Cell Host and Microbe. 32, 3, p. 293-295 3 p.Research output: Contribution to journal › Comment/debate pies 100% Bacteroides fragilis 92% Microbiota 68% Bacteriophages 68% microbiome 67% Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infectionAggarwal, S., Walker, F. C., Weagley, J. S., McCune, B. T., Wu, X., Schriefer, L. A., Makimaa, H., Lawrence, D., Sridhar, P. & Baldridge, M. T., May 2024, In: PLoS pathogens. 20, 5 MAY, e1011961.Research output: Contribution to journal › Article › peer-review Open Access Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferonsKalugotla, G., Marmerstein, V. & Baldridge, M. T., Apr 2024, In: Current Opinion in Immunology. 87, 102425.Research output: Contribution to journal › Review article › peer-review interferon type III 100% Host-Pathogen Interactions 80% Interferon Type I 73% Gastrointestinal Tract 53% Interferons 37% The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytesYomogida, K., Trsan, T., Sudan, R., Rodrigues, P. F., Ulezko Antonova, A., Ingle, H., Luccia, B. D., Collins, P. L., Cella, M., Gilfillan, S., Baldridge, M. T., Oltz, E. M. & Colonna, M., Jan 2024, In: Nature immunology. 25, 1, p. 77-87 11 p.Research output: Contribution to journal › Article › peer-review Intraepithelial Lymphocytes 100% Transcription Factors 58% Interleukin-15 28% STAT5 Transcription Factor 16% Zinc Fingers 12% 2 Scopus citations Age-associated features of norovirus infection analysed in miceKennedy, E. A., Aggarwal, S., Dhar, A., Karst, S. M., Wilen, C. B. & Baldridge, M. T., Jun 2023, In: Nature microbiology. 8, 6, p. 1095-1107 13 p.Research output: Contribution to journal › Article › peer-review Open Access Caliciviridae Infections 100% Norovirus 64% Interferons 60% Viral RNA 36% Infections 31% 5 Scopus citations View all 86 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply We use COOKIEs to help provide and enhance our service and tailor content. By continuing you agree to the use of COOKIEs About web accessibility Report vulnerability