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Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Thomas Brett Associate Professor of Medicine, Associate Professor of Biochemistry and Molecular Biophysics, Associate Professor of Cell Biology and Physiology Division of Pulmonary & Critical Care MedicineRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Biochemistry, Biophysics, and Structural BiologyDBBS - ImmunologyInstitute of Clinical and Translational Sciences (ICTS)Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)Center for the Investigation of Membrane Excitability DiseasesCenter of Regenerative MedicineHope Center for Neurological Disorders  https://orcid.org/0000-0002-6871-6676 Willing to MentorAvailable to Mentor:PhD/MSTP Students, High School Students, Undergraduate Students, Post-Baccalaureate Students, PhD/MSTP Students, Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students, Postdocs, Residents and Fellows 2741 Citations 1994 …2022 Research activity per year Overview Fingerprint Network Research output (47) Similar Profiles (6) Personal profile Research interestsThe Brett lab is focussed on using the methods of structural biology, biophysics, biochemistry, and cellular biology to understand molecular mechanisms underlying disease pathologies. Our current focusses are on chronic inflammatory airway diseases and Alzheimer's disease.Our research on chronic airway disease is focussed on cystic fibrosis. We have identified a unique family of regulator proteins, the CLCA family, that regulate the TMEM16 family of chloride channels. Our research investigates the structural and biophysical mechanisms of CLCA potentiation of TMEM16 channels, as well as their role in airway biology and mucosal immunology.Our research on Alzheimer's disease focusses on microglial receptors and their role in AD pathogenesis. Current focus is on TREM2, a scavenger receptor expressed on microglia that signals for important microglial functions. We use structural, biophysical, and cellular methods to understand how various ligands engage and signal through TREM2.  Lab WebsiteClinical interestscystic fibrosisMentoringMy mentoring approach involves working closely with trainees on all aspects of their project and career objectives. Past trainees have been very successful in obtaining competitive fellowships, and have progressed to prominent independent positions.The Brett lab is committed to support, wellness, diversity, and inclusion. Education activities and interestsI currently serve as Co-Director for the Biochemistry, Biophysics, and Structural Biology (BBSB) PhD program and serve on the steering committee. I am committed to maintaining and increasing the quality of the BBSB program and supporting its students, as well those of other DBBS programs.I serve as a coursemaster for the Structural Biology Journal Club.  Available to Mentor:PhD/MSTP StudentsHigh School StudentsUndergraduate StudentsPost-Baccalaureate StudentsHealth Professions StudentsPostdocsResidents and Fellows Fingerprint Dive into the research topics where Thomas Brett is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 6 Similar Profiles Chloride Channels Medicine & Life Sciences 100% Myeloid Cells Medicine & Life Sciences 62% Clathrin Medicine & Life Sciences 61% Bone Marrow Stromal Antigen 2 Medicine & Life Sciences 59% Proteins Medicine & Life Sciences 54% Protein Chemical Compounds 51% Mucus Medicine & Life Sciences 45% Glycoprotein Chemical Compounds 40% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 1994 2000 2015 2016 2022 40 Article 7 Review article Research output per year Research output per year Production of Eukaryotic Glycoproteins for Structural and Functional Studies Using Expi293F CellsGreven, J. A. & Brett, T. J., Aug 2022, In: Current Protocols. 2, 8, e512.Research output: Contribution to journal › Article › peer-review Open Access Bos taurus structural-GP protein 100% Glycoprotein 55% Glycoproteins 51% Membrane Proteins 49% X Ray Crystallography 41% 2 Scopus citations Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42Kober, D. L., Stuchell-Brereton, M. D., Kluender, C. E., Dean, H. B., Strickland, M. R., Steinberg, D. F., Nelson, S. S., Baban, B., Holtzman, D. M., Frieden, C., Alexander-Brett, J., Roberson, E. D., Song, Y. & Brett, T. J., Mar 2021, In: Alzheimer's and Dementia. 17, 3, p. 475-488 14 p.Research output: Contribution to journal › Article › peer-review Apolipoprotein A-I 100% Apolipoproteins E 92% Myeloid Cells 89% Cell Communication 82% family member 73% 31 Scopus citations Lrp1 is a host entry factor for Rift Valley fever virusGanaie, S. S., Schwarz, M. M., McMillen, C. M., Price, D. A., Feng, A. X., Albe, J. R., Wang, W., Miersch, S., Orvedahl, A., Cole, A. R., Sentmanat, M. F., Mishra, N., Boyles, D. A., Koenig, Z. T., Kujawa, M. R., Demers, M. A., Hoehl, R. M., Moyle, A. B., Wagner, N. D., Stubbs, S. H., & 14 othersCardarelli, L., Teyra, J., McElroy, A., Gross, M. L., Whelan, S. P. J., Doench, J., Cui, X., Brett, T. J., Sidhu, S. S., Virgin, H. W., Egawa, T., Leung, D. W., Amarasinghe, G. K. & Hartman, A. L., Sep 30 2021, In: Cell. 184, 20, p. 5163-5178.e24Research output: Contribution to journal › Article › peer-review Open Access Rift Valley fever virus 100% Glycoprotein 39% Virus Diseases 31% Protein 26% Low-Density Lipoprotein 24% 39 Scopus citations Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A EngagementBerry, K. N. & Brett, T. J., Jan 28 2020, In: Cell Reports. 30, 4, p. 1141-1151.e3Research output: Contribution to journal › Article › peer-review Open Access Chloride Channels 100% Metals 19% Ions 18% von Willebrand Factor 12% Disulfides 12% 10 Scopus citations The Ebola Viral Protein 35 N-Terminus Is a Parallel TetramerChanthamontri, C. K., Jordan, D. S., Wang, W., Wu, C., Lin, Y., Brett, T. J., Gross, M. L. & Leung, D. W., Feb 12 2019, In: Biochemistry. 58, 6, p. 657-664 8 p.Research output: Contribution to journal › Article › peer-review Open Access Nucleocapsid Proteins 100% Tetramer 71% Immune Evasion 60% RNA Viruses 54% Mononegavirales 43% 11 Scopus citations View all 47 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply We use COOKIEs to help provide and enhance our service and tailor content. By continuing you agree to the use of COOKIEs About web accessibility Report vulnerability