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Skip to content Skip to search Skip to footer Neurosurgery Open Menu Back Close Menu Search for: Search Close Search AboutAbout News Diversity, Equity &＃038; Inclusion Contact Us Giving PeoplePeople Clinical Faculty Research Faculty Affiliated Faculty Fellows Residents Advanced Practice Providers Administration Patient CarePatient Care Aneurysms/Vascular Brain Tumors Chiari Malformation / Syringomyelia Epilepsy Hydrocephalus Movement Disorders Pain Pediatrics Peripheral Nerve Spine ResearchResearch Laboratories Clinical TrialsClinical Trials Trials with Outpatient EnrollmentTrials with Outpatient Enrollment Outpatient – Pediatric Outpatient-Spine and Peripheral Nerve Outpatient – Epilepsy and Functional Outpatient-Vascular Outpatient-Oncology Trials with Inpatient EnrollmentTrials with Inpatient Enrollment Inpatient – Oncology Inpatient – Vascular Inpatient- Pediatric Inpatient-Spine and Peripheral Nerve NeurotechnologyNeurotechnology Center for Innovation in Neuroscience and Technology (CINT) NEURO360 EducationEducation Residency Program Fellowship ProgramsFellowship Programs Advanced Surgical Neuro-oncology Fellowship Endovascular Surgical Neuroradiology Fellowship Pediatric Neurosurgery Fellowship Neurosurgical Peripheral Nerve and Spine Fellowship Neurosurgical Complex Spine Fellowship Stereotactic, Functional and Epilepsy Surgery Fellowship Third-year Clerkship Diversity Sub-internship Funding Medical Student Research Opportunities Fourth-year Sub-internship Learning Environment Life Outside the Hospital Join Our Team AppointmentsAppointments Patient imaging Patient forms Open Search Inpatient- Pediatric General Pediatric Neurosurgery PI: Limbrick Protocol ID: 201606086 Short study title: CSF Biomarkers in Treatment of Shunt Infection Short description: The purpose of this study is to understand the evolution of CSF microbiota over time during treatment for shunt infection. CSF will be collected then shipped to an external lab for analysis. Key eligibility criteria: Any sex, any agePatients undergoing treatment for shunt infection with reservoir, EVD, subgaleal shunt, ETV Contact person: Diego Morales, 314-454-4688, [email protected] Enrollment period: Current Pediatric Hydrocephalus PI: Limbrick Protocol ID: 201908133 Short study title: Endoscopic versus Shunt Treatment for Hydrocephalus in Infants Short description: Multi-center (14 sites) RCT comparing ETV+CPC and shunt in infants with hydrocephalus. ETV+CPC offers the potential for shunt-freedom but the cognitive outcome of ETV+CPC is not known in this patient population. The goal of this study is to compare the 2 surgeries in a randomized fashion and to correlate with neurodevelopmental outcomes (Bayley III cognition, language, and motor), brain volumes, fractionated anisotropy in white matter tracts, and CSF markers. Key eligibility criteria: Any sex, age < 52 weeks corrected ageHydrocephalus requiring treatment Contact person: Diego Morales, 314-454-4688, [email protected] Enrollment period: Current PI: Limbrick Protocol ID: 201101887 Short study title: Characterization of Discarded CSF in Ventricular Taps Short description: The goal of this study is to identify potential biomarkers that may aid in determining the optimal timing of intervention for infants with PHH. CSF that would otherwise be discarded will be collected for proteomic analysis. Key eligibility criteria: Any sex, age 5 years and youngerPatient has ventricular access device and will undergo taps as clinically indicatedPreterm infants without PHVD undergoing LPs for sepsis evaluation with subsequent negative CSF culture Contact person: Diego Morales, 314-454-4688, [email protected] Enrollment period: August 2010 &＃8211; current PI: Limbrick Protocol ID: 201203151 Short study title: Characterization of Discarded CSF in Hydrocephalus Short description: The goal of this study is to identify potential biomarkers that may aid in determining diagnostic biomarkers for hydrocephalus and adequacy of treatment. This study involves obtaining blood samples and otherwise discarded CSF samples from patients undergoing neurosurgery for hydrocephalus and unrelated disorders. Key eligibility criteria: Any sex, age 5 years and youngerHydrocephalus: obstructive, non-obstructive, shunt, no shuntNon-hydrocephalus: IPH/IVH, tumor/lesion, TBI, pseudotumor, infection Contact person: Diego Morales, 314-454-4688, [email protected] Enrollment period: 2012 &＃8211; current PI: Limbrick Protocol ID: 201511126 Short study title: Advanced MR Imaging in Congenital Hydrocephalus Short description: Brain development and abnormalities associated with congenital diseases are largely unexplored in the setting of advanced MR imaging. The goal of this study is to use advanced MR imaging to better understand brain development in the setting of congenital hydrocephalus. Key eligibility criteria: Any sex, age 17 years and youngerDiagnosis of congenital hydrocephalusPatient scheduled to undergo surgery for hydrocephalus and a clinically indicated MRI before treatmentPatients able to undergo two sessions of an MRI (30 minutes each). The first session will be either in the same setting as the clinically indicated pre-operative MRI or in a separate setting. The second will be after the surgery and before hospital discharge. Sedation will not be used in research-only MRIs. Contact person: Diego Morales, 314-454-4688, [email protected] Enrollment period: Current PI: Limbrick Protocol ID: 201011763 Short study title: Advanced MR Imaging in Preterm Infants with IVH and PHVD Short description: There is a lack of useful short-term outcome measures in predicting outcome in preterm infants with IVH and PHVD. The goal of this study is to use advanced MRI techniques such as DTI and resting state fMRI to evaluate white matter integrity and cortical development as noninvasive biomarkers in addition to standard of care with cranial ultrasound. Key eligibility criteria: Any sex, age 5 years and youngerDiagnosis of germinal matrix hemorrhage-intraventricular hemorrhage and PHVDIdeally patients should be identified at the time of diagnosis and followed through progression and treatment of PHVD Contact person: Diego Morales, 314-454-4688, [email protected] Enrollment period: Current Pediatric Oncology PI: Limbrick Short study title: Pediatric Neurosurgery Tissue Bank Short description: The purpose of the Pediatric Neurosurgery Tissue Bank is to collect and store tissue samples from patients undergoing surgery. These samples include benign and malignant brain/spine tumors, normal/abnormal brain tissue, cerebrospinal fluid (CSF), bone, blood samples, and other related tissues. Specimens will be collected from the operating room or specialized procedure room in which said tissue is removed. Biological parents and siblings are also eligible to donate blood samples. Data from this tissue bank will be used to better understand disease progression, disease biology, generate realistic animal models of disease, and help to develop newer therapies. Protocol ID: 202002124 Key eligibility criteria: Any sex, any agePatients scheduled to undergo surgical resection for brain/spinal tumor, seizure focus, or brain malformationBiological parents and siblings are also eligible to donate blood samplesPatients at end-of-life are eligible to participate through the Legacy Brain Donation Program Contact person: Corrine Gardner, 314-454-2792, [email protected] Enrollment period: Current Clinical Trials Trials with Inpatient Enrollment Inpatient &＃8211; Oncology Inpatient &＃8211; Vascular Inpatient- Pediatric Inpatient-Spine and Peripheral Nerve Trials with Outpatient Enrollment Department of NeurosurgeryWashington University School of Medicine660 South Euclid AvenueCampus Box 8057St. Louis, MO 63110314-362-3570Contact Us Instagram Twitter YouTube Information Refer a patient Clinical faculty directory Locations Giving Careers Faculty job openings Staff job openings Patients MyChart Patient forms Patient imaging ©2024 Washington University in St. Louis