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Skip to content Skip to search Skip to footer Department of Anesthesiology Open Menu Back Close Menu Search for: Search Close Search Home Patient CarePatient Care For PatientsFor Patients Common Patient Questions about Nerve Blocks Center for Preoperative Assessment and Planning (CPAP) Pain Management Center Research Opportunities Cardiothoracic Anesthesiology DivisionCardiothoracic Anesthesiology Division Adult Cardiothoracic Anesthesiology (ACTA) Fellowship Dual CCM/ACTA Fellowship Overview Current &＃038; Alumni Fellows Critical Care DivisionCritical Care Division Fellowship Overview Letter From Fellowship Program Leadership Fellowship Application Information Fellowship Interview Information Advanced Practice Provider (APP) – Critical Care Medicine Contact Us General AnesthesiaGeneral Anesthesia Abdominal Organ Transplant Fellowship Subspecialties in General Anesthesia Fellowship Application Information Obstetric AnesthesiaObstetric Anesthesia Fellowship Application Information Pain ManagementPain Management Pain Medicine Fellowship  Adult &＃038; Pediatric Pain Dual Fellowship  Current &＃038; Alumni Fellows Fellowship Application Information Pediatric AnesthesiologyPediatric Anesthesiology Pediatric Anesthesiology Fellowship Fellowship Application Information Current Fellows &＃038; Alumni Faculty and Staff Perioperative MedicinePerioperative Medicine Perioperative Care Center for Preoperative Assessment and Planning (CPAP) Our Team Regional and Ambulatory AnesthesiaRegional and Ambulatory Anesthesia Fellowship Overview Fellowship Application Information Current &＃038; Alumni Fellows Past Fellows Our Faculty Contact Us Trauma Anesthesiology Certified Registered Nurse Anesthetists (CRNAs) EducationEducation ResidencyResidency Application Information Training Programs Didactic Curriculum Transitioning to Anesthesia Salary &＃038; Benefits Meet Our Residents Finding a Job Alumni Fellowships Physician-Scientist Development Simulation Centers About St. Louis ResearchResearch Division of Basic Research Division of Clinical and Translational Research (DoCTR)Division of Clinical and Translational Research (DoCTR) DoCTR Newsletter Yellow Phase Ramp-Up Concerns Resources for DoCTR Faculty, Trainee, and staff members Resources for DoCTR Trainees Resources for DoCTR Staff Members Clinical Studies in DoCTR DoCTR TeamDoCTR Team Become a DoCTR Member Washington University Pain Center Center for Clinical Pharmacology INQUIRIINQUIRI The INQUIRI Team INQUIRI’s Approach Working with INQUIRI Publications Contact Us Our CultureOur Culture Diversity, Equity, &＃038; Inclusion Employee Health &＃038; WellnessEmployee Health &＃038; Wellness Health &＃038; Wellness NewsletterHealth &＃038; Wellness Newsletter Health &＃038; Wellness Newsletter Archive Submit a Health &＃038; Wellness Resource Professional Development Peers in Anesthesiology Supporting a Fair Environment Women of WUDA Employee Recognition Hub Our Team GivingGiving How to Give Department Payroll Deduction Jennifer Cole International Education Initiative Endowment FundJennifer Cole International Education Initiative Endowment Fund Jennifer Cole Fund Payroll Deduction AboutAbout Welcome from the Chair News Events Job Opportunities Contact Us Open Search Cardiothoracic Anesthesiology Faculty & Staff Featured News Research Industry Awards Hector-Greene receives FAER Mentored Research Training Grant By Admin • June 16, 2024June 16, 2024 Melissa Hector-Greene, MD, PhD, was recently awarded a Mentored Research Training Grant from the Foundation for Anesthesia Education and Research (FAER) for her project titled, “Pathogenic Mechanisms of R190W Mutation in LMNA-Associated Cardiomyopathy.” This prestigious grant provides $250,000 in funding over two years to support the development of essential skills, the generation of preliminary data, and the publication of research findings. As a cardiac anesthesiologist, Hector-Greene frequently takes care of patients living with heart failure, a condition in which the heart muscle cannot adequately meet the body’s needs for blood and oxygen. While genetic causes of heart failure are relatively rare, studying them offers insight into the fundamental processes that govern normal and pathologic cardiac function. The R190W mutation in the nuclear protein Lamin A (LMNA) has been linked to sudden death, severe heart rhythm disorders, and significant heart failure in affected families, often leading to repeated heart transplants. However, it is not yet understood how this mutation causes these severe issues. Hector-Greene’s study aims to uncover this by using advanced techniques to create new heart cells carrying the LMNA R190W mutation and investigate how the mutation leads to heart failure. The study will also identify cellular pathways that could be targeted for future treatments or prevention. “With the support of the FAER Mentored Research Training Grant, we will explore how the LMNA R190W mutation affects heart muscle function, nuclear stability, and gene activity through a series of tests, advanced imaging techniques, and genetic analyses,” said Hector-Greene. “In the second phase of the study, we will examine how the R190W mutation alters the chemical and physical properties of Lamin A. This research could provide new insights into the role of proteins that help maintain cell structure, like LMNA.” Hector-Greene will lead this research alongside co-mentors from WashU Medicine: Professor of Medicine for Developmental Biology, Pathology and Immunology, and Director of the Center for Cardiovascular Research, Kory Lavine, MD, PhD, and Associate Professor of Biochemistry and Molecular Biophysics, Michael Greenberg, PhD. Hector-Greene completed her residency in anesthesiology at WashU, followed by a fellowship in Cardiothoracic Anesthesiology and a Postdoctoral Research Fellowship, also at WashU. She officially joined the Department of Anesthesiology in July 2023 as a faculty member, with joint appointments in the Division of Cardiothoracic Anesthesiology and the Division of Basic Research. Her long-term career goal as a physician-scientist is to establish a cross-disciplinary research program that uses innovative techniques to understand and answer fundamental questions about heart disease. The FAER Mentored Research Training Grant is highly competitive and is awarded to exceptional faculty members who have completed their core anesthesiology residency training within the past 10 years. This grant provides essential financial support and recognizes the potential of physician-investigators to make significant contributions to their respective fields. An organization of the American Society of Anesthesiologists (ASA), FAER is dedicated to developing the next generation of physician-scientists in anesthesiology and fueling anesthesiology’s future through scientific discovery. More information about FAER and the spring 2024 grant recipients is available on the ASA website. Share this:TwitterLinkedInFacebookEmail Department of AnesthesiologyWashington University School of Medicine660 S. Euclid Ave.St. Louis, MO 63110Contact Us Twitter Resources Intranet Job Opportunities Directory Policies ©2024 Washington University in St. Louis   Loading Comments...   Write a Comment... Email (Required) Name (Required) Website