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Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Joseph Dougherty Professor of Genetics, Professor of Psychiatry Department of GeneticsRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Computational and Systems BiologyDBBS - Human and Statistical GeneticsDBBS - Molecular Genetics and GenomicsDBBS - NeurosciencesDepartment of PsychiatryInstitute of Clinical and Translational Sciences (ICTS)Hope Center for Neurological DisordersIntellectual and Developmental Disabilities Research Center (IDDRC)  https://orcid.org/0000-0002-6385-3997 Willing to MentorAvailable to Mentor:PhD/MSTP Students 4917 Citations 20012024 Research activity per year Overview Fingerprint Network Research output (123) Similar Profiles (6) Personal profile Research interestsOur laboratory is interested in the genetics and genomics of behavior in health and disease. We utilize a variety of techniques, including human molecular genetics, informatics, mouse behavior, in vitro neuroscience, and neuroanatomy. We are continuously developing novel methods for transgenesis, gene manipulation, and transcriptional profiling of the brain. These tools help us to develop mouse models for discovery and modeling of genetic variations based on human patient populations, in order to understand the cellular and molecular underpinnings of behavior. We are particularly focused on neurodevelopmental disorders, including the autism spectrum. Lab Website Available to Mentor:PhD/MSTP Students Fingerprint Dive into the research topics where Joseph Dougherty is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 6 Similar Profiles Genes Medicine & Life Sciences 100% Brain Medicine & Life Sciences 94% Neurons Medicine & Life Sciences 92% Autistic Disorder Medicine & Life Sciences 90% Autism Spectrum Disorder Medicine & Life Sciences 81% Astrocytes Medicine & Life Sciences 61% Neurodevelopmental Disorders Medicine & Life Sciences 59% Gene Expression Medicine & Life Sciences 58% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 2001 2017 2018 2019 2020 2021 2022 2023 2024 108 Article 9 Review article 2 Conference contribution 2 Comment/debate 2 More 1 Chapter 1 Short survey Research output per year Research output per year Characterization of early markers of disease in the mouse model of mucopolysaccharidosis IIIBMcCullough, K. B., Titus, A., Reardon, K., Conyers, S., Dougherty, J. D., Ge, X., Garbow, J. R., Dickson, P., Yuede, C. M. & Maloney, S. E., Dec 2024, In: Journal of neurodevelopmental disorders. 16, 1, 16.Research output: Contribution to journal › Article › peer-review Open Access Mucopolysaccharidoses 100% Lysosomal Storage Diseases 19% Fear 18% Startle Reflex 18% Diffusion Tensor Imaging 15% Examining Sex Differences in Autism HeritabilitySandin, S., Yip, B. H. K., Yin, W., Weiss, L. A., Dougherty, J. D., Fass, S., Constantino, J. N., Hailin, Z., Turner, T. N., Marrus, N., Gutmann, D. H., Sanders, S. J. & Christoffersson, B., 2024, (Accepted/In press) In: JAMA psychiatry.Research output: Contribution to journal › Article › peer-review Open Access Autism Spectrum Disorder 100% Autistic Disorder 96% Sex Characteristics 90% Sex Ratio 31% Paternal Age 20% 1 Scopus citations Visual Deprivation during Mouse Critical Period Reorganizes Network-Level Functional ConnectivityChen, S., Rahn, R. M., Bice, A. R., Bice, S. H., Padawer-Curry, J. A., Hengen, K. B., Dougherty, J. & Culver, J. P., May 8 2024, In: Journal of Neuroscience. 44, 19, e1019232024.Research output: Contribution to journal › Article › peer-review Open Access A comprehensive assay of social motivation reveals sex-specific roles of autism-associated genes and oxytocinMaloney, S. E., Sarafinovska, S., Weichselbaum, C., McCullough, K. B., Swift, R. G., Liu, Y. & Dougherty, J. D., Jun 26 2023, In: Cell Reports Methods. 3, 6, 100504.Research output: Contribution to journal › Article › peer-review Open Access Oxytocin 100% Assays 86% Autistic Disorder 74% Genes 70% Motivation 59% 2 Scopus citations A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivoLagunas, T., Plassmeyer, S. P., Fischer, A. D., Friedman, R. Z., Rieger, M. A., Selmanovic, D., Sarafinovska, S., Sol, Y. K., Kasper, M. J., Fass, S. B., Aguilar Lucero, A. F., An, J. Y., Sanders, S. J., Cohen, B. A. & Dougherty, J. D., Dec 2023, In: Communications Biology. 6, 1, 1151.Research output: Contribution to journal › Article › peer-review Open Access neurons 100% Neurons 74% Mental Disorders 65% assays 64% autism 61% View all 123 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply We use COOKIEs to help provide and enhance our service and tailor content. By continuing you agree to the use of COOKIEs About web accessibility Report vulnerability