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See publications by year Featured publications Fluorescence lifetime imaging captures neuromodulator dynamics at multiple time scales A new study from Yao Chen’s lab reveals that some fluorescent-intensity–based sensors also show fluorescence lifetime responses, expanding observations of neuromodulator activity over time and distance. Key regulator of decision-making pinpointed in brain (Links to an external site) Findings shed light on mental illnesses, including obsessive-compulsive disorder, anxiety How does waste leave the brain? (Links to an external site) Professor Krikor Dikranian and Assistant Professor Peter Bayguinov among authors of new study in Nature describing a route that serves as a passageway to clear fluid waste from brain. Introducing a new conceptual framework for astrocyte function In Nature Neuroscience, Thomas Papouin and colleagues describe the role of astrocytes in “contextual guidance.” Sleep disruption—whether from loss of sleep or “social jet lag”—affects thermoregulation Fruit flies seek out warmer temperatures when they experience sleep deprivation or fragmentation or when faced with a shifted sleep schedule, similar to when people stay up late and sleep in on the weekend. How do developing brains assemble and organize themselves? (Links to an external site) Brain areas are marked by distinct activity patterns very early, marsupial study published in PNAS by the Richards Lab shows. Posts pagination 1 of 5 Next Page Publications by year 2024 Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells So CL, Robitaille M, Sadras F, McCullough MH, Milevskiy MJG, Goodhill GJ, Roberts-Thomson SJ, Monteith GR. April 17, 2024. In: Commun Biol. 7(1):467. doi: 10.1038/s42003-024-06163-z. Functional organization of posterior parietal cortex circuitry based on inferred information flow Kang JU, Mooshagian E, Snyder LH. April 5, 2024. In: Cell Rep. 43(4):114028. doi: 10.1016/j.celrep.2024.114028. Online ahead of print. F-box protein FBXB-65 regulates anterograde transport of the kinesin-3 motor UNC-104 through a PTM near its cargo-binding PH domain Sabharwal V, Boyanapalli SPP, Shee A, Nonet ML, Nandi A, Chaudhuri D, Koushika SP. April 1, 2024. In: J Cell Sci. 137(7):jcs261553. doi: 10.1242/jcs.261553. Epub 2024 Apr 16. Skeletal abnormalities in mice with Dnmt3a missense mutations Bell-Hensley A, Beard DC, Feeney K, Zheng H, Jiang Y, Zhang X, Liu J, Gabel H, McAlinden A. March 22, 2024. In: Bone. 117085. doi: 10.1016/j.bone.2024.117085. Online ahead of print. F-box protein FBXB-65 regulates anterograde transport of a Kinesin-3 motor UNC-104 through a PTM near its cargo-binding PH domain Sabharwal V, Boyanapalli SPP, Shee A, Nonet ML, Nandi A, Chaudhuri D, Koushika SP. March 13, 2024. In: J Cell Sci. jcs.261553. doi: 10.1242/jcs.261553. Online ahead of print. Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales Ma P, Chen P, Tilden EI, Aggarwal S, Oldenborg A, Chen Y. February 23, 2024. In: Sci Adv. eadi0643. doi: 10.1126/sciadv.adi0643. Epub 2024 Feb 21. Circuit-based intervention corrects excessive dentate gyrus output in the fragile X mouse model Deng P-Y, Kumar A, Cavalli V, Klyachko VA. February 12, 2024. In: eLife. 12:RP92563. doi: 10.7554/eLife.92563. Identification of direct connections between the dura and the brain Smyth LCD, Xu D, Okar SV, Dykstra T, Rustenhoven J, Papadopoulos Z, Bhasiin K, Kim MW, Drieu A, Mamuladze T, Blackburn S, Gu X, Gaitán MI, Nair G, Storck SE, Du S, White MA, Bayguinov P, Smirnov I, Dikranian K, Reich DS, Kipnis J. February 7, 2024. In: Nature. doi: 10.1038/s41586-023-06993-7. Online ahead of print. A Cre-dependent reporter mouse for quantitative real-time imaging of protein kinase A activity dynamics Tilden EI, Maduskar A, Oldenborg A, Sabatini BL, Chen Y. February 6, 2024. In: Sci Rep. 14(1):3054. doi: 10.1038/s41598-024-53313-8. Motor control: Snake neurons speed up Bello-Rojas S, Bagnall MW. February 5, 2024. In: Curr Biol. 34(3):R98-R99. doi: 10.1016/j.cub.2023.12.060. Tempo and mode of gene expression evolution in the brain across primates Rickelton K, Zintel TM, Pizzollo J, Miller E, Ely JJ, Raghanti MA, Hopkins WD, Hof PR, Sherwood CC, Bauernfeind AL, Babbitt CC. January 26, 2024. In: eLife. 13:e70276. doi: 10.7554/eLife.70276. Online ahead of print. Diverse axonal morphologies of individual callosal projection neurons reveal new insights into brain connectivity Pal S, Lim JWC, Richards LJ. January 24, 2024. In: Curr Opin Neurobiol. 84:102837. doi: 10.1016/j.conb.2023.102837. Online ahead of print. Curiosity: primate neural circuits for novelty and information seeking Monosov IE. January 23, 2024. In: Nat Review Neurosci. doi: 10.1038/s41583-023-00784-9. Online ahead of print. TIMely connections: APOE4, aging, and Alzheimer’s Li Q. January 9, 2024. In: Immunity. 57(1):8-10. doi: 10.1016/j.immuni.2023.12.015. A neural mechanism for conserved value computations integrating information and rewards Bromberg-Martin ES, Feng Y-Y, Ogasawara T, White JK, Zhang K, Monosov IE. January 4, 2024. In: Nat Neurosci. doi: 10.1038/s41593-023-01511-4. Online ahead of print. 2023 MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes Nettles SA, Ikeuchi Y, Lefton KB, Abbasi L, Erickson A, Agwu C, Papouin T, Bonni A, Gabel HW. December 12, 2023. In: Cell Rep. 42(12):113538. doi: 10.1016/j.celrep.2023.113538. Online ahead of print. Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits Beard DC, Zhang X, Wu DY, Martin JR, Erickson A, Boua JV, Hamagami N, Swift RG, McCullough KB, Ge X, Bell-Hensley A, Zheng H, Palmer CW, Fuhler NA, Lawrence AB, Hill CA, Papouin T, Noguchi KK, McAlinden A, Garbow JR, Dougherty JD, Maloney SE,  Gabel HW. November 10, 2023. In: Cell Rep. 42(11):113411. doi: 10.1016/j.celrep.2023.113411. Online ahead of print. Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling Marom R, Zhang B, Washington ME, Song I-W, Burrage LC, Rossi VC, Berrier AS, Lindsey A, Lesinski J, Nonet ML, Chen J, Baldridge D, Silverman GA, Sutton VR, Rosenfeld JA, Tran AA, Hicks MJ, Murdock DR, Dai H, M, Jhangiani SN, Muzny DM, Gibbs RA, Caswell R, Pottinger C, Cilliers D, Stals K; Undiagnosed Diseases Network; Eyre D, Krakow D, Schedl T, Pak SC, Lee BH. November 7, 2023. In: PLoS Genet. 19(11):e1011005. doi: 10.1371/journal.pgen.1011005. Online ahead of print. UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously Pohl F, Germann AL, Mao J, Hou S, Bakare B, Kong Thoo Lin P, Yates K, ML Nonet, Akk G, Kornfeld K, Held JM. November 3, 2023. In: Sci Adv. 9(44):eadh2584. doi: 10.1126/sciadv.adh2584. Epub 2023 Nov 1. Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila Anthoney N, Tainton-Heap L, Luong H, Notaras E, Kewin AB, Zhao Q, Perry T, Batterham P, Shaw PJ, van Swinderen B. November 1, 2023. In: eLife. 12:RP88198. doi: 10.7554/eLife.88198. Loss-of-function variants in ZEB1 cause dominant anomalies of the corpus callosum with favourable cognitive prognosis Heide S, Argilli E, Valence S, Boutaud L, Roux N, Mignot C, Nava C, Keren B, Giraudat K, Faudet A, Gerasimenko A, Garel C, Blondiaux E, Rastetter A, Grevent D, Le C, Mackenzie L, Richards L, Attié-Bitach T, Depienne C, Sherr E, Héron D. October 19, 2023. In: J Med Genet. jmg-2023-109293. doi: 10.1136/jmg-2023-109293. Online ahead of print. A conceptual framework for astrocyte function Murphy-Royal C, Ching S, Papouin T. October 19, 2023. In: Nat Neurosci. doi: 10.1038/s41593-023-01448-8. Online ahead of print. Non-uniform temporal scaling of developmental processes in the mammalian cortex Paolino A, Haines EH, Bailey EJ, Black DA, Moey C, García-Moreno F, Richards LJ, Suárez R, Fenlon LR. September 23, 2023. In: Nat Commun. 14(1):5950. doi: 10.1038/s41467-023-41652-5. Single genomic enhancers drive experience-dependent GABAergic plasticity to maintain sensory processing in the adult cortex Roethler O, Zohar E, Cohen-Kashi Malina K, Bitan L, Gabel HW, Spiegel I. September 6, 2023. In: Neuron. 111(17):2693-2708.e8. doi: 10.1016/j.neuron.2023.05.026. Epub 2023 Jun 23. Organization of vestibular circuits for postural control in zebrafish Liu Z, Bagnall MW. August 25, 2023. In: Curr Opin Neurobiol. 82:102776. doi: 10.1016/j.conb.2023.102776. Online ahead of print. Aicardi Syndrome is a genetically heterogeneous disorder Ha TT, Burgess R, Newman M, Moey C, Mandelstam SA, Gardner AE, Ivancevic AM, Pham D, Kumar R, Smith N, Patel C, Malone S, Ryan MM, Calvert S, van Eyk CL, Lardelli M, Berkovic SF, Leventer RJ, Richards LJ, Scheffer IE, Gecz J, Corbett MA. July 31, 2023. In: Genes (Basel). 14(8):1565. doi: 10.3390/genes14081565. Striatal mGlu5-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways Jong Y-JI, Izumi Y, Harmon SK, Zorumski CF, O’Malley KL. June 22, 2023. In: J Biol Chem. 104949. doi: 10.1016/j.jbc.2023.104949. Online ahead of print. Single genomic enhancers drive experience-dependent GABAergic plasticity to maintain sensory processing in the adult cortex Roethler O, Zohar E, Cohen-Kashi Malina K, Bitan L, Gabel HW, Spiegel I. June 20, 2023. In: Neuron. S0896-6273(23)00399-9. doi: 10.1016/j.neuron.2023.05.026. Online ahead of print. Local translation in microglial processes is required for efficient phagocytosis Vasek MJ, Mueller SM, Fass SB, Deajon-Jackson JD, Liu Y, Crosby HW, Koester SK, Yi J, Li Q, Dougherty JD. June 5, 2023. In: Nat Neurosci. doi: 10.1038/s41593-023-01353-0. Online ahead of print. Cortical activity emerges in region-specific patterns during early brain development Suárez R, Bluett T, McCullough MH, Avitan L, Black DA, Paolino A, Fenlon LR, Goodhill GJ, Richards LJ. May 30, 2023. In: PNAS. 120(22):e2208654120. doi: 10.1073/pnas.2208654120. Epub 2023 May 22. Sleep deprivation, sleep fragmentation, and social jet lag increase temperature preference in Drosophila Roach ST, Ford MC, Simhambhatla V, Loutrianakis V, Farah H, Li Z, Periandri EM, Abdalla D, Huang I, Kalra A, Shaw PJ. May 19, 2023. In: Front Neurosci. 17:1175478. doi: 10.3389/fnins.2023.1175478. eCollection 2023. Local and long-distance organization of prefrontal cortex circuits in the marmoset brain Watakabe A, Skibbe H, Nakae K, Abe H, Ichinohe N, Rachmadi MF, Wang J, Takaji M, Mizukami H, Woodward A, Gong R, Hata J, Van Essen DC, Okano H, Ishii S, Yamamori T. May 9, 2023. In: Neuron. S0896-6273(23)00338-0. doi: 10.1016/j.neuron.2023.04.028. Online ahead of print. A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages Brioschi S, Belk JA, Peng V, Molgora M, Rodrigues PF, Nguyen KM, Wang S, Du S, Wang W-L, Grajales-Reyes GE, Ponce JM, Yuede CM, Li Q, Baer JM, DeNardo DG, Gilfillan S, Cella M, Satpathy AT, Colonna M. May 9, 2023. In: Immunity. 56(5):1027-1045.e8. doi: 10.1016/j.immuni.2023.01.028. Epub 2023 Feb 14. NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons Hamagami N, Wu DY, Clemens AW, Nettles SA, Li A, Gabel HW. May 4, 2023. In: Mol Cell. 83(9):1412-1428.e7. doi: 10.1016/j.molcel.2023.04.001. Epub 2023 Apr 24. Rapid generation of C. elegans single-copy transgenes combining RMCE and drug selection Nonet ML. April 20, 2023. In: Genetics. iyad072. doi: 10.1093/genetics/iyad072. Online ahead of print. Whole-brain imaging of freely-moving zebrafish Hasani H, Sun J, Zhu SI, Rong Q, Willomitzer F, Amor R, McConnell G, Cossairt O, Goodhill GJ. April 17, 2023. In: Front Neurosci. 17:1127574. doi: 10.3389/fnins.2023.1127574. eCollection 2023. Spike-phase coupling patterns reveal laminar identity in primate cortex Davis ZW, Dotson NM, Franken TP, Muller L, Reynolds JH. April 17, 2023. In: eLife. 12:e84512. doi: 10.7554/eLife.84512. Online ahead of print. Structural gray matter alterations in glioblastoma and high-grade glioma-A potential biomarker of survival Lamichhane B, Luckett PH, Dierker D, Park KY, Burton H, Olufawo M, Trevino G, Lee JJ, Daniel AGS, Hacker CD, Marcus DS, Shimony JS, Leuthardt EC. April 14, 2023. In: Neurooncol Adv. 5(1):vdad034. doi: 10.1093/noajnl/vdad034. eCollection 2023 Jan-Dec. Julia for biologists Roesch E, Greener JG, MacLean AL, Nassar H, Rackauckas C, Holy TE, Stumpf MPH. April 6, 2023. In: Nature Methods. doi: 10.1038/s41592-023-01832-z. Online ahead of print. Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy Zuo C, Baer JM, Knolhoff BL, Belle JI, Liu X, Alarcon De La Lastra A, Fu C, Hogg GD, Kingston NL, Breden MA, Dodhiawala PB, Zhou DC, Lander VE, James CA, Ding L, Lim K-H, Fields RC, Hawkins WG, Weber JD, Zhao G, DeNardo DG. June 5, 2023. In: J Exp Med. 220(6):e20212062. doi: 10.1084/jem.20212062. Epub 2023 Mar 23. BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy Geng Y, Li P, Butler A, Wang B, Salkoff L, Magleby KL. May 1, 2023. In: J Gen Physiol. 155(5):e202213302. doi: 10.1085/jgp.202213302. Epub 2023 Mar 30. Integration of feedforward and feedback information streams in the modular architecture of mouse visual cortex Burkhalter A, D’Souza RD, Ji W, Meier AM. March 27, 2023. In: Ann Rev Neurosci. doi:10.1146/annurev-neuro-083122-021241. Online ahead of print. Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization Goldblatt D, Huang S, Greaney MR, Hamling KR, Voleti V, Perez-Campos C, Patel KB, Li W, Hillman EMC, Bagnall MW, Schoppik D. March 7, 2023. In: Current Biology. S0960-9822(23)00188-4. doi: 10.1016/j.cub.2023.02.048. Online ahead of print. A response to claims of emergent intelligence and sentience in a dish Balci F, Ben Hamed S, Boraud T, Bouret S, Brochier T, Brun C, Cohen JY, Coutureau E, Deffains M, Doyère V, Gregoriou GG, Heimel JA, Kilavik BE, Lee D, Leuthardt EC, Mainen ZF, Mathis M, IE Monosov, Naudé J, Orsborn AL, Padoa-Schioppa C, Procyk E, Sabatini B, Sallet J, Sandi C, Schall JD, Soltani A, Svoboda K, Wilson CRE, Zimmermann J. March 1, 2023. In: Neuron. 111(5):604-605. doi: 10.1016/j.neuron.2023.02.009. Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration Xu J, Farsad HL, Hou Y, Barclay K, Lopez BA, Yamada S, Saliu IO, Shi Y, Knight WC, Bateman RJ, Benzinger TLS, Yi JJ, Li Q, Wang T, Perlmutter JS, Morris JC, Zhao Z. March, 2023. In: Nature Aging. 3(3):346-365. doi: 10.1038/s43587-023-00363-8. Epub 2023 Feb 9. Shared and disease-specific glial gene expression changes in neurodegenerative diseases Zhao G. March, 2023. In: Nature Aging. 3(3):246-247. doi: 10.1038/s43587-023-00378-1. Epub 2023 Feb 13. Spinal interneurons: Diversity and connectivity in motor control Sengupta M, Bagnall MW. Feb 28, 2023. In: Annu Rev Neurosci. doi: 10.1146/annurev-neuro-083122-025325. Online ahead of print. How to make a vampire Smith TD, Prufrock KA, DeLeon VB. Feb 20, 2023. In: Anat Rec (Hoboken). doi: 10.1002/ar.25179. Online ahead of print. Mirror movements and callosal dysgenesis in a family with a DCC mutation: Neuropsychological and neuroimaging outcomes Knight JL, Barker MS, Edwards TJ, Barnby JM, Richards LJ, Robinson GA. Feb 19, 2023. In: Cortex. 161:38-50. doi: 10.1016/j.cortex.2023.01.008. Online ahead of print. Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration Feng R, Muraleedharan Saraswathy V, Mokalled MH, Cavalli V. Feb 14, 2023. In: PNAS. 120(7):e2215906120. doi: 10.1073/pnas.2215906120. Epub 2023 Feb 10. From perception to behavior: The neural circuits underlying prey hunting in larval zebrafish Zhu SI, Goodhill GJ. Feb 1, 2023. In: Front Neural Circuits. 17:1087993. doi: 10.3389/fncir.2023.1087993. eCollection 2023. Age-related differences in resting-state functional connectivity from childhood to adolescence Sanders AFP, Harms MP, Kandala S, Marek S, Somerville LH, Bookheimer SY, Dapretto M, Thomas KM, Van Essen DC, Yacoub E, Barch DM. February 1, 2023. In: Cereb Cortex. bhad011. doi: 10.1093/cercor/bhad011. Online ahead of print. Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain Pan S, Yang PH, DeFreitas D, Ramagiri S, Bayguinov PO, Hacker CD, Snyder AZ, Wilborn J, Huang H, Koller GM, Raval DK, Halupnik GL, Sviben, Achilefu S, Tang R, Haller G, Quirk JD, Fitzpatrick JAJ, Esakky P, Strahle JM. January 27, 2023. In: Nat Commun. 14(1):453. doi: 10.1038/s41467-023-36083-1. Monosynaptic restriction of the anterograde herpes simplex virus strain H129 for neural circuit tracing Fischer KB, Collins HK, Pang Y, Roy DS, Zhang Y, Feng G, Li S-J, Kepecs A, Callaway EM. January 6, 2023. In: J Comp Neurol. doi: 10.1002/cne.25451. Online ahead of print. fmr1 mutation alters the early development of sensory coding and hunting and social behaviors in larval zebrafish Zhu SI, McCullough MH, Pujic Z, Sibberas J, Sun B, Darveniza T, Bucknall B, Avitan L, Goodhill GJ. January 3, 2023. In: J Neurosci. JN-RM-1721-22. doi: 10.1523/JNEUROSCI.1721-22.2022. Online ahead of print. 2022 Polyphasic circadian neural circuits drive differential activities in multiple downstream rhythmic centers Liang X, Holy TE, Taghert PH. December 29, 2022. In: Curr Biol. S0960-9822(22)01961-3. doi: 10.1016/j.cub.2022.12.025. Online ahead of print. Clonally related, Notch-differentiated spinal neurons integrate into distinct circuits Bello-Rojas S, Bagnall MW. December 29, 2022. In: eLife. 11:e83680. doi: 10.7554/eLife.83680. Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity Brazill JM, Shin D, Magee K, Majumdar A, Shen IR, Cavalli V, Scheller EL. December 28, 2022. In: Mol Metab. 101664. doi: 10.1016/j.molmet.2022.101664. Online ahead of print. Primates chunk simultaneously-presented memoranda Holmes CD, Ching S, Snyder LH. December 13, 2022. In: Front Behav Neurosci. 16:1060193. doi: 10.3389/fnbeh.2022.1060193. eCollection 2022. Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment Szadai Z, Pi H-J, Chevy Q, Ócsai K, Albeanu DF, Chiovini B, Szalay G, Katona G, Kepecs A, Rózsa B. November 23, 2022. In: eLife. 11:e78815. doi: 10.7554/eLife.78815. Cortical adaptation of the night monkey to a nocturnal niche environment: a comparative non-invasive T1w/T2w myelin study Ikeda T, Autio JA, Kawasaki A, Takeda C, Ose T, Takada M, Van Essen DC, Glasser MF, Hayashi T. November 18, 2022. In: Brain Struct Funct. doi: 10.1007/s00429-022-02591-x. Online ahead of print. Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation Petroff 2nd JT, Dietzen NM, Santiago-McRae E, Deng B, Washington MS, Chen LJ, Moreland KT, Deng Z, Rau M, Fitzpatrick JAJ, Yuan P, Joseph TT, Hénin J, Brannigan G, Cheng WWL. November 17, 2022. In: Nat Commun. 13(1):7017. doi: 10.1038/s41467-022-34813-5. Dopamine in the rodent tail of striatum regulates behavioral variability in response to threatening novel objects Pai J, Monosov IE. November 16, 2022. In: Neuron. 110(22):3653-3655. doi: 10.1016/j.neuron.2022.10.019. Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition Palmer EE, Pusch M … [35 authors] Richards LJ … [60 authors] Kalscheuer VM. November 16, 2022. In: Mol Psychiatry. doi: 10.1038/s41380-022-01852-9. Online ahead of print. The zona incerta in control of novelty seeking and investigation across species Monosov IE, Ogasawara T, Haber SN, Heimel JA, Ahmadlou M. November 15, 2022. In: Curr Opin Neurobiol. 77:102650. doi: 10.1016/j.conb.2022.102650. Online ahead of print. Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel Mount J, Maksaev G, Summers BT, Fitzpatrick JAJ, Yuan P. November 12, 2022. In: Nat Commun. 13(1):6904. doi: 10.1038/s41467-022-34737-0. 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