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Skip to content Skip to search Skip to footer Hope Center for Neurological Disorders Open Menu Back Close Menu Search for: Search Close Search AboutAbout Leadership &＃038; Advising Hope Happens Donate Faculty MembersFaculty Members Membership Guidelines Research GroupsResearch Groups Axon Injury &＃038; Repair Clocks &＃038; Sleep Club Lipid Metabolism Lysosome Processing &＃038; Transport Neurodegeneration/HPAN Neurogenetics &＃038; Transcriptomics NeuroRestorative Therapy CoresCores Alafi Neuroimaging Animal Surgery DNA/RNA Purification In Vivo Microdialysis Viral Vectors Microelectrode Array (MEA) Funding/AwardsFunding/Awards Pilot ProjectsPilot Projects Active Pilot Projects Past Pilot Project Awards Hope Center Awards Hope Center Scholar Just-in-Time (JIT) Awards EducationEducation Monday Noon Seminars Annual Hope Center Retreat Hope Center Lecture Neurobiology of Disease (Bio5663) NewsNews Publications HPAN and BioMed 21 IRC Open Search HPAN and BioMed 21 IRC Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN) About HPAN The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN) is an interdisciplinary program that aims to find diagnostic tools and effective treatments for neurodegenerative diseases by investigating their underlying cause. As part of the larger Hope Center for Neurological Disorders, HPAN faculty work together to, Discover genetic alterations that lead to familial forms of neurodegenerative disease or alter disease risk for sporadic cases. Understand the biochemical and cell biological processes that control metabolism of proteins that misfold in neurodegenerative disorders.Apply models of neurodegenerative disorders to better understand disease pathogenesis and to develop treatments.Perform translational studies in humans to understand metabolism of proteins prone to aggregate in neurodegenerative disorders to develop better diagnostic and treatment methods. Accomplishing these goals will provide insight to underlying molecular mechanisms of disease, and better ways to diagnose and treat neurodegenerative diseases. HPAN laboratories use complementary approaches to address questions of protein aggregation in disease. A subset of these labs are located in the BJC Institute of Health, an inititative of BioMed 21. HPAN Director David Holtzman, MD Neurodegeneration/HPAN Group Meetings: Monthly meetings provide an opportunity to share progress and get feedback. About BioMed 21 The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN) is one of five Interdisciplinary Research Centers (IRCs) selected by the Dean of Washington University School of Medicine. As a BioMed 21 IRC, HPAN was awarded support from the Dean, and space in the new BJC Institute of Health (BJC-IH). Below are those HPAN labs that are based in the BJC-IH. Randall Bateman, MD Charles F. and Joanne Knight Distinguished Professor, WashU Neurology Phone: 314-747-7066 Email: [email protected] Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics, treatments Anil Cashikar, PhD Associate Professor, WashU Psychiatry Phone: 314-273-1863 Email: [email protected] Oxysterols in Alzheimer’s disease David Holtzman, MD Hope Center Scientific Director; Barbara Burton and Reuben M. Morriss III Distinguished Professor, WashU Neurology Phone: 314-747-0286 Email: [email protected] Twitter Cellular/Molecular/ Biomarker studies of Alzheimer’s Disease and neonatal brain injury Celeste Karch, PhD Professor, WashU Psychiatry Phone: 314-747-3161 Email: [email protected] Twitter Molecular mechanisms underlying tauopathies Geraldine Kress, PhD Assistant Professor, WashU Neurology Phone: 314-362-5503 Email: [email protected] Role of circadian function on memory during aging and Alzheimer’s disease (AD) progression Eric Landsness, MD, PhD Assistant Professor, WashU Neurology Email: [email protected] Twitter Connection between plasticity-dependent mechanisms for stroke recovery and sleep-dependent plasticity Jin-Moo Lee, MD, PhD Andrew B. &＃038; Gretchen P. Jones Professor and Chair, WashU Neurology Phone: 314-362-7382 Email: [email protected] Understanding mechanisms of neurologic disease Brendan Lucey, MD Professor, WashU Neurology Phone: 314-747-3805 Email: [email protected] Twitter Understanding the relationship between sleep, the amyloid beta diurnal pattern, and Alzheimer’s disease Erik Musiek, MD, PhD Charlotte &＃038; Paul Hagemann Professor, WashU Neurology Phone: 314-747-5412 Email: [email protected] Twitter Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases Steven Paul, MD Professor, WashU Psychiatry Phone: 314-273-1863 Email: [email protected] Understanding how apoE contributes to the clearance and metabolism of Aβ in Alzheimer’s disease Anneliese Schaefer, JD, PhD Hope Center Executive Director; Professor, WashU Neurology Phone: 314-747-3429 Email: [email protected] Motor neuron disease Gregory Zipfel, MD Ralph G. Dacey Distinguished Professor and Chair, WashU Neurosurgery Phone: 314-747-8871 Email: [email protected] Twitter Cerebral amyloid angiopathy; Aneurysmal subarachnoid hemorrhage Hope Center for Neurological DisordersMSC 8111-96-07-71224370 Duncan Ave.St. Louis, Missouri [email protected] What&＃8217;s happening? News Publications Add me to the email distribution list! Support our cause Contact us Donate ©2024 Washington University in St. Louis
