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Skip to content Skip to search Skip to footer Needleman Center for Neurometabolism and Axonal Therapeutics Open Menu Back Close Menu Search for: Search Close Search Home AboutAbout Leadership Ashrafi Lab Website DiAntonio Lab Website Milbrandt Lab Website News Publications Donate Contact Open Search Combatting Neurodegenerative Disease by Advancing Research in Cellular Metabolism and Axon Maintenance Activating Mutations of Sarm1 Enriched in ALS January 18, 2022Sarm1 mutations are not common in ALS patients, but a careful examination of the ones that do occur by Dr. Joseph Bloom and colleagues has shown that they tend to cause Sarm1 to be constitutively active and occur more frequently in ALS patients than in the general population. This research, published in Molecular Neurodegeneration, suggests […] Protein structure studies demonstrate how SARM1 senses cellular energy status to trigger axon degeneration April 16, 2021Two recent articles published by Needleman Center researchers dissect the structure of SARM1, an enzyme responsible for initiating programmed axon degeneration, and shed light on how the balance of key cellular metabolites regulate its activity. SARM1 forms an octamer in which each monomer contains an N-terminal autoinhibitory domain, domains that mediate multimerization, and a C-terminal […] See all Needleman Center News Needleman Center for Neurometabolism and Axonal TherapeuticsWashington University School of Medicine4523 Clayton AvenueCouch Building, Rm 6206St. Louis, MO 63114 ©2024 Washington University in St. Louis