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Skip to main navigation Skip to search Skip to main content Research Profiles at Washington University School of Medicine Home Help & FAQ Home Profiles Departments, Divisions and Centers Research output Search by expertise, name or affiliation View Scopus Profile Helen McNeill Larry J Shapiro and Carol-Ann Uetake-Shapiro Professor, Professor of Developmental Biology Department of Developmental BiologyRoy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)DBBS - Cancer BiologyDBBS - Developmental, Regenerative and Stem Cell BiologyDBBS - Molecular Cell BiologyDBBS - Molecular Genetics and GenomicsInstitute of Clinical and Translational Sciences (ICTS)Center of Regenerative MedicineHope Center for Neurological DisordersSiteman Cancer Center  https://orcid.org/0000-0003-1126-5154 Willing to MentorAvailable to Mentor:PhD/MSTP Students 6577 Citations 1990 …2023 Research activity per year Overview Fingerprint Network Research output (99) Similar Profiles (6) Personal profile Research interestsThe overall goal of research in the McNeill lab is to understand at a cellular level how tissue growth and tissue organization are regulated during normal development, and how loss of this control leads to human disease.We use Drosophila and mouse genetics for in vivo analysis, as well as tissue culture and organoid approaches. One major focus of the lab is the investigation of Fat cadherins. Fat cadherins are enormous cell adhesion molecules that regulates cell proliferation, metabolism and cell polarity in all metazoa. We use Drosophila as a genetically tractable organism to investigate the basic and conserved mechanisms of Fat function and the control of Hippo pathway activity, and then extend our work to mammalian systems. Our most recent work has uncovered a novel and exciting role for Fat cadherins in regeneration.We found that binding of Fat to its ligand Ds promotes Fat phosphorylation and signaling to the Hippo pathway. Now we are using proteomic screening to identify Fat cadherin pathway effectors, using BioID to identify interaction partners in a near physiological context. We also found that Ft cadherins undergo sequential cleavages release a cytosolic fragment that is imported into mitochondria (Fat-mito), where it binds Ndufv2, a component of CI.Our work on Fat and the Hippo pathway in mouse models has revealed a critical and unsuspected role for the Hippo growth control pathway in morphogenesis. Using whole animal conditional and organ-culture approaches, we found that loss of NF2 or LATS or overexpression of YAP leads to growth and elongation of the collecting ducts in the absence of branching morphogenesis. To understand better how branching is affected, we will conduct high-resolution time-lapse imaging of the induction of branching morphogenesis. We will also assay tissue tension at junctions in the developing kidney with laser ablation and reporter assays.In addition to our studies on Fat and the Hippo pathway, a new area of exciting research in the lab focuses on a novel nuclear membrane protein we isolated in genetic screens that we have found is essential for chromatin structure and fertility in flies, mice and fish. This project is taking us into exploring how changes in the nuclear envelope impact gene expression and cell fate. Lab Website Available to Mentor:PhD/MSTP Students Fingerprint Dive into the research topics where Helen McNeill is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 6 Similar Profiles Cell Polarity Medicine & Life Sciences 100% Drosophila Medicine & Life Sciences 63% Cadherins Medicine & Life Sciences 62% Fats Medicine & Life Sciences 41% Morphogenesis Medicine & Life Sciences 29% Diptera Medicine & Life Sciences 25% Growth Medicine & Life Sciences 25% Cell Adhesion Molecules Medicine & Life Sciences 24% View full fingerprint Collaborations and top research areas from the last five years Recent external collaboration on country/territory level. Dive into details by clicking on the dots or Select a country/territory from the list Dive into details Select a country/territory to view shared publications and projects Close Select a country/territory from the list Explore network further Research output Research output per year 1990 2005 2009 2010 2013 2014 2015 2016 2017 2018 2019 2020 2022 2023 71 Article 16 Review article 4 Chapter 4 Comment/debate 4 More 2 Editorial 2 Short survey Research output per year Research output per year Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathwayFulford, A. D., Enderle, L., Rusch, J., Hodzic, D., Holder, M. V., Earl, A., Oh, R. H., Tapon, N. & McNeill, H., May 1 2023, In: The Journal of cell biology. 222, 5Research output: Contribution to journal › Article › peer-review Open Access Fats 100% Growth 67% Cadherins 22% Ligands 15% Proteins 8% 2 Scopus citations Fat and Dachsous cadherins in mammalian developmentKasiah, J. & McNeill, H., Jan 2023, Cell Polarity in Development and Disease. TEPASS, ULRICH. (ed.). Academic Press Inc., p. 223-244 22 p. (Current Topics in Developmental Biology; vol. 154).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review Cadherins 100% Fats 74% Drosophila 26% Mammals 24% Mutation 23% SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced MetaplasiaWillet, S. G., Thanintorn, N., McNeill, H., Huh, S. H., Ornitz, D. M., Huh, W. J., Hoft, S. G., DiPaolo, R. J. & Mills, J. C., Jan 2023, In: CMGH. 16, 3, p. 325-339 15 p.Research output: Contribution to journal › Article › peer-review Open Access Metaplasia 100% Neck 69% Stomach 65% Wounds and Injuries 44% Homeostasis 24% 1 Scopus citations The Hippo PathwayMcneill, H., Jan 1 2022, Encyclopedia of Cell Biology: Volume 1-6, Second Edition. Elsevier, Vol. 4. p. 116-124 9 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review Developmental 100% Phosphotransferases 63% Cell Polarity 50% Physiological Phenomena 42% Morphogenesis 41% The Hippo pathway regulates axis formation and morphogenesis in HydraBrooun, M., Salvenmoser, W., Dana, C., Sudol, M., Steele, R., Hobmayer, B. & McNeill, H., Jul 19 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 29, e2203257119.Research output: Contribution to journal › Article › peer-review Open Access Hydra 100% Morphogenesis 65% Cnidaria 49% Wnt Signaling Pathway 36% Long-Acting Thyroid Stimulator 26% 4 Scopus citations View all 99 Research outputs Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. 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